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EDITORIAL Lung Cancer An Emerging Epidemic in the human immunodeficiency virus-Infected Population Alain Makinson, MD,*† Jean-Louis Pujol, MD, PhD,‡ Vincent Le Moing, MD,*† and Jacques Reynes, MD, PhD*† s opportunistic infections and acquired immune deficiency syndrome (AIDS)-related Acancers are decreasing in the human immunodeficiency virus (HIV)-infected popula- tion since the advent of highly active antiretroviral therapy (HAART), new causes of morbidity and mortality are emerging, such as cardiovascular diseases and non-AIDS- 1–4 defining cancers (NADCs). The general aging of the HIV-infected populations in resource-rich settings, because of an increasing life expectancy approaching that of the general population in some successfully treated groups, also explains this shift to 5,6 nonopportunistic diseases. In resource-rich setting studies, lung cancer has the highest 3,7 incidence rate of all NADCs, and despite the advent of HAART, its incidence rate remains increased in comparison with the non-HIV-infected population. The review by Pakkala and Ramalingam focuses on epidemiological, clinical, and management of lung cancers in HIV-infected patients and helps us to disentangle future perspectives of research. This review underscores the increased incidence and the clinical particularities of lung cancer in the HIV-infected population in comparison with the HIV-negative counterparts, including an increased proportion of advanced stages
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Nov 1, 2010
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