Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Loss of Galectin-3 Expression in Mucinous Colorectal Carcinomas is Associated With 5′CpG Island Methylation in Tunisian Patients

Loss of Galectin-3 Expression in Mucinous Colorectal Carcinomas is Associated With 5′CpG Island... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Loss of Galectin-3 Expression in Mucinous Colorectal Carcinomas is Associated With 5 CpG Island Methylation in Tunisian Patients Lilia Kria Ben Mahmoud, MSc,* Amira Arfaoui, MSc,* Mariem Khiari, MSc,* Ines Chaar, MSc,* Olfa El Amine, MD,w Abdel Majid Ben Hmida, MD,z Lasaad Gharbi, MD,y Sabeh Regaya Mzabi, MD,w and Saadia Bouraoui, MD*w NH2-terminal domain contains only 12 amino-acid Abstract: The b-galactoside-binding protein galectin-3 (gal-3) residues that control its cellular targeting, and the has pleitropic biological functions and has been implicated in COOH-terminal domain contains the carbohydrate- cell growth, differentiation, adhesion, RNA processing, apop- recognition domains consisting of 140 amino-acid resi- 7–9 tosis, and malignant transformation. To investigate the pattern dues, which define the molecule as a galectin. It is an of inactivation of the gal-3 gene (LGALS3) in colorectal cancers intracellular and extracellular lectin that interacts with (CRC), we studied a series of Tunisian patients with CRC to intracellular glycoproteins, cell surface molecules, and 10–12 identify abnormal methylation in LGALS3 promoter using a extracellular matrix proteins. Gal-3 is involved in methylation-specific PCR. We also examined the gal-3 gene diverse biological processes including cell growth, differ- expression by reverse transcription-PCR and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Loss of Galectin-3 Expression in Mucinous Colorectal Carcinomas is Associated With 5′CpG Island Methylation in Tunisian Patients

Download PDF
8 pages

Loading next page...
 
/lp/wolters-kluwer-health/loss-of-galectin-3-expression-in-mucinous-colorectal-carcinomas-is-AuYTp45SO0

References (48)

Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181f869bb
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Loss of Galectin-3 Expression in Mucinous Colorectal Carcinomas is Associated With 5 CpG Island Methylation in Tunisian Patients Lilia Kria Ben Mahmoud, MSc,* Amira Arfaoui, MSc,* Mariem Khiari, MSc,* Ines Chaar, MSc,* Olfa El Amine, MD,w Abdel Majid Ben Hmida, MD,z Lasaad Gharbi, MD,y Sabeh Regaya Mzabi, MD,w and Saadia Bouraoui, MD*w NH2-terminal domain contains only 12 amino-acid Abstract: The b-galactoside-binding protein galectin-3 (gal-3) residues that control its cellular targeting, and the has pleitropic biological functions and has been implicated in COOH-terminal domain contains the carbohydrate- cell growth, differentiation, adhesion, RNA processing, apop- recognition domains consisting of 140 amino-acid resi- 7–9 tosis, and malignant transformation. To investigate the pattern dues, which define the molecule as a galectin. It is an of inactivation of the gal-3 gene (LGALS3) in colorectal cancers intracellular and extracellular lectin that interacts with (CRC), we studied a series of Tunisian patients with CRC to intracellular glycoproteins, cell surface molecules, and 10–12 identify abnormal methylation in LGALS3 promoter using a extracellular matrix proteins. Gal-3 is involved in methylation-specific PCR. We also examined the gal-3 gene diverse biological processes including cell growth, differ- expression by reverse transcription-PCR and

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: May 1, 2011

There are no references for this article.