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Loss of BAP1 Expression Occurs Rarely to Never in Colorectal Adenocarcinoma

Loss of BAP1 Expression Occurs Rarely to Never in Colorectal Adenocarcinoma LETTER TO THE EDITOR Somatic biallelic inactivation of BAP1, (CRC). This is unfortunate as metastatic Loss of BAP1 Expression rarely also associated with germline CRC may be in the clinical differential mutation (OMIM 614327), has been diagnosis of BAP1-negative tumors, Occurs Rarely to demonstrated in uveal and cutaneous particularly mesothelioma presenting Never in Colorectal melanomas, mesotheliomas, clear cell with pleural effusion or cholangio- renal carcinoma, cholangiocarcinoma, carcinoma with an intrahepatic mass. Adenocarcinoma and basal cell carcinoma but is very We therefore sought to investigate BAP1 rare in ovarian serous carcinoma, expression in a large series of CRCs. To the Editor: pancreatic carcinoma, and lung ad- Tissue microarray (TMA) slides 3–8 enocarcinoma. from a well-characterized cohort of BRCA1-associated protein 1 There is little data on BAP1 ex- CRCs were obtained—cohort summar- (BAP1) is a deubiquitinating enzyme 1,2 pression in colorectal adenocarcinoma ized in Ahadi et al. Briefly, this cohort with tumor suppressor functions. FIGURE 1. Serial sections of colorectal adenocarcinoma are stained with both hematoxylin and eosin (A, C) and BAP1 immunohistochemistry (B, D). The tumor cells demonstrate diffuse strong nuclear expression of BAP1. Of note, nuclear expression of BAP1 is also present in non-neoplastic stromal cells which act as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Loss of BAP1 Expression Occurs Rarely to Never in Colorectal Adenocarcinoma

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1062-3345
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000506
Publisher site
See Article on Publisher Site

Abstract

LETTER TO THE EDITOR Somatic biallelic inactivation of BAP1, (CRC). This is unfortunate as metastatic Loss of BAP1 Expression rarely also associated with germline CRC may be in the clinical differential mutation (OMIM 614327), has been diagnosis of BAP1-negative tumors, Occurs Rarely to demonstrated in uveal and cutaneous particularly mesothelioma presenting Never in Colorectal melanomas, mesotheliomas, clear cell with pleural effusion or cholangio- renal carcinoma, cholangiocarcinoma, carcinoma with an intrahepatic mass. Adenocarcinoma and basal cell carcinoma but is very We therefore sought to investigate BAP1 rare in ovarian serous carcinoma, expression in a large series of CRCs. To the Editor: pancreatic carcinoma, and lung ad- Tissue microarray (TMA) slides 3–8 enocarcinoma. from a well-characterized cohort of BRCA1-associated protein 1 There is little data on BAP1 ex- CRCs were obtained—cohort summar- (BAP1) is a deubiquitinating enzyme 1,2 pression in colorectal adenocarcinoma ized in Ahadi et al. Briefly, this cohort with tumor suppressor functions. FIGURE 1. Serial sections of colorectal adenocarcinoma are stained with both hematoxylin and eosin (A, C) and BAP1 immunohistochemistry (B, D). The tumor cells demonstrate diffuse strong nuclear expression of BAP1. Of note, nuclear expression of BAP1 is also present in non-neoplastic stromal cells which act as

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Oct 1, 2018

References

  • BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
  • BAP1, a candidate tumor suppressor protein that interacts with BRCA1
  • Loss of expression of BAP1 predicts longer survival in mesothelioma
  • Loss of expression of BAP1 is a useful adjunct which strongly supports the diagnosis of mesothelioma in effusion cytology
  • Loss of BAP1 expression occurs frequently in intrahepatic cholangiocarcinoma
  • Loss of BAP1 expression is very rare in peritoneal and gynaecological serous adenocarcinomas and can be useful in the differential diagnosis with abdominal mesothelioma
  • Loss of BAP1 expression is very rare in pancreatic ductal adenocarcinoma
  • Loss of expression of BAP1 is very rare in non-small cell lung carcinoma
  • Loss of Hes1 expression is associated with poor prognosis in colorectal adenocarcinoma
  • Somatic mutation of a tumor suppressor gene BAP1 is rare in breast, prostate, gastric and colorectal cancers
  • Prognostic significance of BRCA1-associated protein 1 in colorectal cancer