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RESEARCH ARTICLE Loss of ARID1A Expression is Related to Gastric Cancer Progression, Epstein-Barr Virus Infection, and Mismatch Repair Deficiency Nayoung Han, MD,* Min A. Kim, MD, PhD,* Hye Seung Lee, MD, PhD,*w and Woo Ho Kim, MD, PhD* Key Words: AT-rich interactive domain 1A (ARID1A), im- Abstract: The AT-rich interactive domain 1A (ARID1A) gene munohistochemistry, Epstein-Barr virus infections, mismatch encodes a member of the switch/sucrose nonfermentable (SWI- repair, stomach neoplasms SNF) chromatin remodeling complex, and is considered to work as (Appl Immunohistochem Mol Morphol 2015;00:000–000) a tumor suppressor in concert with p53. We investigated the clinical significance of ARID1A protein expression in gastric cancer (GC), and examined its association with Epstein-Barr virus–associated (EBV) GC, mismatch repair (MMR) deficiency, and p53 alteration. We performed immunohistochemistry for ARID1A in 417 GC astric cancer (GC) is the fourth most commonly di- specimens using tissue microarray. EBV infection was examined Gagnosed cancer and the third leading cause of cancer- using EBV-encoded small RNA in situ hybridization. Evaluation of related death among men worldwide. At present, the MMR protein deficiency and p53 alteration was performed using outcome for patients with advanced GC is still bleak. immunohistochemistry, and microsatellite instability status was also Efforts have
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jun 1, 2015
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