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Left Ventricular Myocardial Function in Children With Pulmonary Hypertension Relation to Right Ventricular Performance and Hemodynamics

Left Ventricular Myocardial Function in Children With Pulmonary Hypertension Relation to Right... Pulmonary Arterial Hypertension Left Ventricular Myocardial Function in Children With Pulmonary Hypertension Relation to Right Ventricular Performance and Hemodynamics Dale A. Burkett, MD; Cameron Slorach, RDCS; Sonali S. Patel, MD, PhD; Andrew N. Redington, MBBS, MD; D. Dunbar Ivy, MD; Luc Mertens, MD, PhD; Adel K. Younoszai, MD; Mark K. Friedberg, MD Background—Through ventricular interdependence, pulmonary hypertension (PH) induces left ventricular (LV) dysfunction. We hypothesized that LV strain/strain rate, surrogate measures of myocardial contractility, are reduced in pediatric PH and relate to invasive hemodynamics, right ventricular strain, and functional measures of PH. Methods and Results—At 2 institutions, echocardiography was prospectively performed in 54 pediatric PH patients during cardiac catheterization, and in 54 matched controls. Patients with PH had reduced LV global longitudinal strain (LS; −18.8 [−17.3 to −20.4]% versus −20.2 [−19.0 to −20.9]%; P=0.0046) predominantly because of reduced basal (−12.9 [−10.8 to −16.3]% versus −17.9 [−14.5 to −20.7]%; P<0.0001) and mid (−17.5 [−15.5 to −19.0]% versus −21.1 [−19.1 to −23.0]%; P<0.0001) septal strain. Basal global circumferential strain was reduced (−18.7 [−15.7 to −22.1]% versus −20.6 [−19.0 to −22.5]%; P=0.0098), as were septal and free-wall segments. Mid circumferential strain was reduced within the free-wall. Strain rates were reduced in similar http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Left Ventricular Myocardial Function in Children With Pulmonary Hypertension Relation to Right Ventricular Performance and Hemodynamics

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References (27)

Copyright
© 2015 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.115.003260
pmid
26259580
Publisher site
See Article on Publisher Site

Abstract

Pulmonary Arterial Hypertension Left Ventricular Myocardial Function in Children With Pulmonary Hypertension Relation to Right Ventricular Performance and Hemodynamics Dale A. Burkett, MD; Cameron Slorach, RDCS; Sonali S. Patel, MD, PhD; Andrew N. Redington, MBBS, MD; D. Dunbar Ivy, MD; Luc Mertens, MD, PhD; Adel K. Younoszai, MD; Mark K. Friedberg, MD Background—Through ventricular interdependence, pulmonary hypertension (PH) induces left ventricular (LV) dysfunction. We hypothesized that LV strain/strain rate, surrogate measures of myocardial contractility, are reduced in pediatric PH and relate to invasive hemodynamics, right ventricular strain, and functional measures of PH. Methods and Results—At 2 institutions, echocardiography was prospectively performed in 54 pediatric PH patients during cardiac catheterization, and in 54 matched controls. Patients with PH had reduced LV global longitudinal strain (LS; −18.8 [−17.3 to −20.4]% versus −20.2 [−19.0 to −20.9]%; P=0.0046) predominantly because of reduced basal (−12.9 [−10.8 to −16.3]% versus −17.9 [−14.5 to −20.7]%; P<0.0001) and mid (−17.5 [−15.5 to −19.0]% versus −21.1 [−19.1 to −23.0]%; P<0.0001) septal strain. Basal global circumferential strain was reduced (−18.7 [−15.7 to −22.1]% versus −20.6 [−19.0 to −22.5]%; P=0.0098), as were septal and free-wall segments. Mid circumferential strain was reduced within the free-wall. Strain rates were reduced in similar

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Aug 1, 2015

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