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Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus Prevalence and Association With Myocardial and Vascular Disease

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus Prevalence and Association With... Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus Prevalence and Association With Myocardial and Vascular Disease Mikael Kjaer Poulsen, MD; Jan Erik Henriksen, MD, PhD; Jordi Dahl, MD; Allan Johansen, MD, DMSc; Oke Gerke, PhD; Werner Vach, PhD; Torben Haghfelt, MD, DMSc; Poul Flemming Høilund-Carlsen, MD, DMSc; Henning Beck-Nielsen, MD, DMSc; Jacob Eifer Møller, MD, PhD, DMSc Background—Although type 2 diabetes mellitus is a risk factor for developing congestive heart failure, the mechanism leading to heart failure is unclear. We examined the prevalence of left ventricular (LV) systolic and diastolic dysfunction in patients with type 2 diabetes mellitus in relation to vascular function and myocardial perfusion. Methods and Results—A prospective observational study of 305 patients with type 2 diabetes mellitus (diabetes duration, 4.55.3 years) referred consecutively to a diabetes clinic were screened for LV systolic and diastolic function by echocardiography. Vascular function was estimated using noninvasive estimation of pulse pressure, carotid arterial compliance, total arterial compliance, and valvulo-arterial impedance. The prevalences of LV diastolic dysfunction and left atrial (LA) volume index 32 mL/m were 40% and 32%, respectively. The prevalence of myocardial ischemia on myocardial perfusion scintigraphy was more frequent in patients with grade 2 diastolic dysfunction and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus Prevalence and Association With Myocardial and Vascular Disease

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ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.109.855510
pmid
19846730
Publisher site
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Abstract

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus Prevalence and Association With Myocardial and Vascular Disease Mikael Kjaer Poulsen, MD; Jan Erik Henriksen, MD, PhD; Jordi Dahl, MD; Allan Johansen, MD, DMSc; Oke Gerke, PhD; Werner Vach, PhD; Torben Haghfelt, MD, DMSc; Poul Flemming Høilund-Carlsen, MD, DMSc; Henning Beck-Nielsen, MD, DMSc; Jacob Eifer Møller, MD, PhD, DMSc Background—Although type 2 diabetes mellitus is a risk factor for developing congestive heart failure, the mechanism leading to heart failure is unclear. We examined the prevalence of left ventricular (LV) systolic and diastolic dysfunction in patients with type 2 diabetes mellitus in relation to vascular function and myocardial perfusion. Methods and Results—A prospective observational study of 305 patients with type 2 diabetes mellitus (diabetes duration, 4.55.3 years) referred consecutively to a diabetes clinic were screened for LV systolic and diastolic function by echocardiography. Vascular function was estimated using noninvasive estimation of pulse pressure, carotid arterial compliance, total arterial compliance, and valvulo-arterial impedance. The prevalences of LV diastolic dysfunction and left atrial (LA) volume index 32 mL/m were 40% and 32%, respectively. The prevalence of myocardial ischemia on myocardial perfusion scintigraphy was more frequent in patients with grade 2 diastolic dysfunction and

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Jan 1, 2010

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