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Original Articles Mustafa Kurt, MD; Jianwen Wang, PhD, MD; Guillermo Torre-Amione, PhD, MD; Sherif F. Nagueh, MD Background—Abnormalities in left ventricular (LV) structure and function occur in patients with diastolic heart failure (DHF). The reasons for the transition from asymptomatic dysfunction to heart failure need better definition, including noninvasive measurements that can detect the transition. Methods and Results—In 64 patients undergoing right heart catheterization, simultaneous echocardiographic imaging was performed. As a control group, 27 healthy subjects were included. There were 25 with ejection factor (EF) 50%, 20 in DHF, and 19 with normal EF and LV hypertrophy but not in heart failure (diastolic dysfunction). LV volumes, mass, left atrial (LA) volumes and EF, annular atrial velocity (a), and LA strain during systole (LA ), and atrial contraction (LA ) were measured. The ratio of wedge pressure to LA strain was used as an index of LA stiffness, as was the ratio A S of E/e to LA strain. All 3 patient groups had increased LA volumes and depressed LA EF, a, and LA strain, with S A no significant difference between patients with DHF and diastolic dysfunction in LA systolic function indices, LV mass, LA volumes, LV, and arterial
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Jan 1, 2009
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