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“Vascular Age” Is Advanced in Children With Atherosclerosis-Promoting Risk Factors

“Vascular Age” Is Advanced in Children With Atherosclerosis-Promoting Risk Factors Original Articles “Vascular Age” Is Advanced in Children With Atherosclerosis-Promoting Risk Factors Joseph Le; Danna Zhang, MS; Spencer Menees; Jie Chen, PhD; Geetha Raghuveer, MD, MPH Background—Obesity and familial dyslipidemia in children are associated with accelerated atherosclerosis by pathological examination. We sought to determine whether these children had increased carotid artery intima-media thickness (CIMT), a measure of subclinical atherosclerosis similar to 45-year-old adults. Adult CIMT percentile tables were used for comparison because normative CIMT data for children are limited. Methods and Results—Seventy children, ages 6 to 19 years, with obesity- and atherosclerosis-promoting risk factors such as dyslipidemia, hypertension, insulin resistance, and tobacco smoke exposure, or with familial dyslipidemia, underwent carotid artery ultrasound. Advanced “vascular age” (VA) was defined as having maximum CIMT that was 25th percentile for race- and sex-matched 45-year-old adults. Mean age was 13.03.3 years. Forty (57%) of 70 children had body mass index 95th percentile for age and sex. Maximum CIMT for obese children was 0.530.05 mm and for familial dyslipidemic children was 0.520.04 mm. Advanced VA was seen in 30 (75%) of obese children and 22 (73%) of familial dyslipidemic children. Thirty (75%) of obese children had 3 mutable atherosclerosis-promoting risk factors; these children had http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

“Vascular Age” Is Advanced in Children With Atherosclerosis-Promoting Risk Factors

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References (51)

ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.109.880070
pmid
19920030
Publisher site
See Article on Publisher Site

Abstract

Original Articles “Vascular Age” Is Advanced in Children With Atherosclerosis-Promoting Risk Factors Joseph Le; Danna Zhang, MS; Spencer Menees; Jie Chen, PhD; Geetha Raghuveer, MD, MPH Background—Obesity and familial dyslipidemia in children are associated with accelerated atherosclerosis by pathological examination. We sought to determine whether these children had increased carotid artery intima-media thickness (CIMT), a measure of subclinical atherosclerosis similar to 45-year-old adults. Adult CIMT percentile tables were used for comparison because normative CIMT data for children are limited. Methods and Results—Seventy children, ages 6 to 19 years, with obesity- and atherosclerosis-promoting risk factors such as dyslipidemia, hypertension, insulin resistance, and tobacco smoke exposure, or with familial dyslipidemia, underwent carotid artery ultrasound. Advanced “vascular age” (VA) was defined as having maximum CIMT that was 25th percentile for race- and sex-matched 45-year-old adults. Mean age was 13.03.3 years. Forty (57%) of 70 children had body mass index 95th percentile for age and sex. Maximum CIMT for obese children was 0.530.05 mm and for familial dyslipidemic children was 0.520.04 mm. Advanced VA was seen in 30 (75%) of obese children and 22 (73%) of familial dyslipidemic children. Thirty (75%) of obese children had 3 mutable atherosclerosis-promoting risk factors; these children had

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Jan 1, 2010

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