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A. Catalano, Sabrina Rodilossi, M. Rippo, P. Caprari, A. Procopio (2004)
Induction of Stem Cell Factor/c-Kit/Slug Signal Transduction in Multidrug-resistant Malignant Mesothelioma Cells*Journal of Biological Chemistry, 279
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KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomasThe Journal of Pathology, 202
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The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE‐A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminomaHistopathology, 42
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K. Araki, G. Ishii, T. Yokose, K. Nagai, K. Funai, K. Kodama, Y. Nishiwaki, A. Ochiai (2003)
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Stem cell factor receptor (c‐kit, CD117) is expressed on blast cells from most immature types of acute myeloid malignancies but is also a characteristic of a subset of acute promyelocytic leukaemiaBritish Journal of Haematology, 92
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REVIEW KIT (CD117): A Review on Expression in Normal and Neoplastic Tissues, and Mutations and Their Clinicopathologic Correlation Markku Miettinen, MD and Jerzy Lasota, MD Key Words: KIT, CD117, gastrointestinal stromal tumor, lymphoma, Abstract: CD117 (KIT) is a type III receptor tyrosine kinase melanoma, seminoma, carcinoma, mutation operating in cell signal transduction in several cell types. Normally (Appl Immunohistochem Mol Morphol 2005;13:205–220) KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor. This leads to a phosphorylation cascade ultimately activating various transcription factors in different cell types. Such activation regulates apoptosis, cell differentiation, proliferation, IT receptor tyrosine kinase was assigned cluster number chemotaxis, and cell adhesion. KIT-dependent cell types include KCD117 during the fifth international conference of mast cells, some hematopoietic stem cells, germ cells, melanocytes, leukocyte typing in Boston in November 1993. KIT is and Cajal cells of the gastrointestinal tract, and neoplasms of these a tyrosine kinase growth factor receptor expressed in diverse cells are examples of KIT-positive tumors. Other KIT-positive normal cell types, including Cajal cells of the gastrointestinal tract, cells include epithelial cells in skin adnexa, breast, and subsets of mast cells and subsets of hematopoietic stem cells, germ cells, cerebellar neurons.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Sep 1, 2005
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