Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Meijgaarden, M. Haks, N. Caccamo, F. Dieli, T. Ottenhoff, S. Joosten (2015)
Human CD8+ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell SubsetPLoS Pathogens, 11
Sarah Fidler, Kholoud Porter, Fiona Ewings, J. Frater, Gita Ramjee, David Cooper, Helen Rees, Martin Fisher, Mauro Schechter, P. Kaleebu, G. Tambussi, Sabine Kinloch, J. Miro, Anthony Kelleher, Myra McClure, Steve Kaye, Michelle Gabriel, Rodney Phillips, J. Weber, Abdel Babiker (2013)
Short-course antiretroviral therapy in primary HIV infection.The New England journal of medicine, 368 3
J. Minang, Matthew Trivett, D. Bolton, C. Trubey, J. Estes, Yuan Li, J. Smedley, R. Pung, M. Rosati, R. Jalah, G. Pavlakis, B. Felber, M. Piatak, M. Roederer, J. Lifson, D. Ott, C. Ohlen (2009)
Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones in Rhesus Macaques during Acute InfectionThe Journal of Immunology, 184
Daniele Cary, K. Fujinaga, B. Peterlin (2016)
Molecular mechanisms of HIV latency.The Journal of clinical investigation, 126 2
K. Butler, P. Gavin, S. Coughlan, A. Rochford, Sinead Donagh, O. Cunningham, H. Poulsom, S. Watters, N. Klein (2015)
Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth.The Pediatric infectious disease journal, 34 3
S. Migueles, M. Sabbaghian, W. Shupert, M. Bettinotti, F. Marincola, Lisa Martino, C. Hallahan, S. Selig, David Schwartz, J. Sullivan, M. Connors (2000)
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.Proceedings of the National Academy of Sciences of the United States of America, 97 6
Gina Graziani, J. Angel (2015)
Evaluating the efficacy of therapeutic HIV vaccines through analytical treatment interruptionsJournal of the International AIDS Society, 18
Rasmus Offersen, S. Nissen, T. Rasmussen, L. Østergaard, P. Denton, O. Søgaard, M. Tolstrup (2016)
A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T CellsJournal of Virology, 90
K. Luzuriaga, H. Gay, C. Ziemniak, Keri Sanborn, M. Somasundaran, K. Rainwater-Lovett, J. Mellors, D. Rosenbloom, D. Persaud (2015)
Viremic relapse after HIV-1 remission in a perinatally infected child.The New England journal of medicine, 372 8
(2016)
Reports that SIV-specific CD8 T cells contribute to control SIV replication in lymphoid tissues outside of the B-cell follicles in elite controller macaques
J. Thornhill, J. Inshaw, S. Oomeer, P. Kaleebu, D. Cooper, G. Ramjee, M. Schechter, G. Tambussi, J. Fox, J. Miro, J. Weber, A. Babiker, K. Porter, S. Fidler (2014)
Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infectionJournal of the International AIDS Society, 17
P. Mudd, M. Martins, A. Ericsen, D. Tully, K. Power, Alexander Bean, Shari Piaskowski, L. Duan, Aaron Seese, A. Gladden, K. Weisgrau, Jessica Furlott, Young-il Kim, Marlon Santana, E. Rakasz, S. Capuano, N. Wilson, M. Bonaldo, R. Galler, D. Allison, M. Piatak, A. Haase, J. Lifson, Todd Allen, D. Watkins (2012)
Vaccine-induced CD8+ T cells control AIDS virus replicationNature, 491
M. Pinkevych, D. Cromer, M. Tolstrup, Andrew Grimm, D. Cooper, S. Lewin, O. Søgaard, T. Rasmussen, S. Kent, A. Kelleher, M. Davenport (2015)
HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV RemissionPLoS Pathogens, 11
James Williams, J. Hurst, W. Stöhr, N. Robinson, Helen Brown, M. Fisher, S. Kinloch, D. Cooper, M. Schechter, G. Tambussi, S. Fidler, M. Carrington, A. Babiker, J. Weber, K. Koelsch, A. Kelleher, R. Phillips, J. Frater (2014)
HIV-1 DNA predicts disease progression and post-treatment virological controleLife, 3
L. Ruíz, J. Martinez-Picado, J. Romeu, R. Paredes, M. Zayat, S. Marfil, E. Negredo, G. Sirera, C. Tural, B. Clotet (2000)
Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppressionAIDS, 14
R. Calin, C. Hamimi, S. Lambert-Niclot, G. Carcelain, Jonathan Bellet, L. Assoumou, R. Tubiana, V. Calvez, Y. Dudoit, D. Costagliola, B. Autran, C. Katlama (2016)
Treatment interruption in chronically HIV-infected patients with an ultralow HIV reservoirAIDS, 30
J. Conway, A. Perelson (2015)
Post-treatment control of HIV infectionProceedings of the National Academy of Sciences, 112
A. Chapuis, Corey Casper, Steve Kuntz, Jia Zhu, Annelie Tjernlund, K. Diem, C. Turtle, Melinda Cigal, Roxanne Velez, Stanley Riddell, Lawrence Corey, Philip Greenberg (2011)
HIV-specific CD8 (cid:1) T cells from HIV (cid:1) individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo
J. Sung, S. Lam, C. Garrido, N. Archin, C. Rooney, C. Bollard, D. Margolis (2015)
Expanded cytotoxic T-cell lymphocytes target the latent HIV reservoir.The Journal of infectious diseases, 212 2
F. Mbitikon-Kobo, M. Bonneville, R. Sékaly, L. Trautmann (2012)
Ex vivo measurement of the cytotoxic capacity of human primary antigen-specific CD8 T cells.Journal of immunological methods, 375 1-2
V. Wyl, S. Gianella, M. Fischer, B. Niederoest, H. Kuster, M. Battegay, E. Bernasconi, M. Cavassini, A. Rauch, B. Hirschel, P. Vernazza, R. Weber, B. Joos, H. Günthard (2011)
Early Antiretroviral Therapy During Primary HIV-1 Infection Results in a Transient Reduction of the Viral Setpoint upon Treatment InterruptionPLoS ONE, 6
S. Freel, R. Picking, G. Ferrari, Haitao Ding, C. Ochsenbauer, J. Kappes, J. Kirchherr, K. Soderberg, K. Weinhold, C. Cunningham, T. Denny, J. Crump, M. Cohen, A. McMichael, B. Haynes, G. Tomaras (2012)
Initial HIV-1 Antigen-Specific CD8+ T Cells in Acute HIV-1 Infection Inhibit Transmitted/Founder Virus ReplicationJournal of Virology, 86
S. Hansen, Julia Ford, Matthew Lewis, A. Ventura, Colette Hughes, Lia Coyne-Johnson, Nathan Whizin, K. Oswald, R. Shoemaker, Tonya Swanson, Alfred Legasse, M. Chiuchiolo, C. Parks, M. Axthelm, J. Nelson, M. Jarvis, M. Piatak, J. Lifson, L. Picker (2011)
Profound early control of highly pathogenic SIV by an effector-memory T cell vaccineNature, 473
Lodi (2012)
Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversionArch Intern Med, 172
K. Bartholomeeusen, K. Fujinaga, Yanhui Xiang, Yanhui Xiang, B. Peterlin (2013)
Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription*The Journal of Biological Chemistry, 288
T. Chun, J. Justement, Susan Moir, C. Hallahan, L. Ehler, Shuying Liu, M. McLaughlin, M. Dybul, J. Mican, A. Fauci (2001)
Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies.Proceedings of the National Academy of Sciences of the United States of America, 98 1
D. Richman, D. Margolis, M. Delaney, W. Greene, D. Hazuda, R. Pomerantz (2009)
The Challenge of Finding a Cure for HIV InfectionScience, 323
Huabiao Chen, Z. Ndhlovu, Dongfang Liu, Lindsay Porter, J. Fang, S. Darko, M. Brockman, T. Miura, Z. Brumme, A. Schneidewind, A. Piechocka-Trocha, K. Cesa, J. Sela, T. Cung, I. Toth, F. Pereyra, Xu Yu, D. Douek, D. Kaufmann, Todd Allen, B. Walker (2012)
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infectionNature Immunology, 13
T. Henrich, Zixin Hu, Jonathan Li, G. Sciaranghella, M. Busch, S. Keating, S. Gallien, N. Lin, Francoise Giguel, Laura Lavoie, V. Ho, P. Armand, R. Soiffer, M. Sagar, A. LaCasce, D. Kuritzkes (2013)
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.The Journal of infectious diseases, 207 11
J. Blazkova, T. Chun, Bietel Belay, D. Murray, J. Justement, E. Funk, Amy Nelson, C. Hallahan, S. Moir, P. Wender, A. Fauci (2012)
Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy.The Journal of infectious diseases, 206 5
P. Hunt (2012)
HIV and Inflammation: Mechanisms and ConsequencesCurrent HIV/AIDS Reports, 9
D. Allan, Eric Lepin, V. Braud, C. O'Callaghan, A. McMichael (2002)
Tetrameric complexes of HLA-E, HLA-F, and HLA-G.Journal of immunological methods, 268 1
G. Pietra, C. Romagnani, Claudia Manzini, L. Moretta, M. Mingari (2010)
The Emerging Role of HLA-E-Restricted CD8+ T Lymphocytes in the Adaptive Immune Response to Pathogens and TumorsJournal of Biomedicine and Biotechnology, 2010
Richard Jones, R. O’Connor, S. Mueller, M. Foley, G. Szeto, D. Karel, M. Lichterfeld, C. Kovacs, M. Ostrowski, A. Trocha, D. Irvine, B. Walker (2014)
Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-LymphocytesPLoS Pathogens, 10
Chloe Slichter, David Friedrich, Rebecca Smith, P. Walsh, G. Mize, Julie Czartoski, M. McElrath, N. Frahm (2014)
Measuring inhibition of HIV replication by ex vivo CD8⁺ T cells.Journal of immunological methods, 404
R. Koup, J. Safrit, Yun-zhen Cao, C. Andrews, G. McLeod, W. Borkowsky, C. Farthing, D. Ho (1994)
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeJournal of Virology, 68
I. Pandrea, T. Gaufin, R. Gautam, J. Kristoff, D. Mandell, D. Montefiori, B. Keele, R. Ribeiro, R. Veazey, C. Apetrei (2011)
Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell DepletionPLoS Pathogens, 7
G. Darcis, A. Kula, S. Bouchat, K. Fujinaga, F. Corazza, Amina Ait-Ammar, N. Delacourt, A. Mélard, K. Kabeya, C. Vanhulle, Benoit Driessche, J. Gatot, T. Cherrier, L. Pianowski, L. Gama, C. Schwartz, J. Vila, A. Burny, N. Clumeck, M. Moutschen, S. Wit, B. Peterlin, C. Rouzioux, O. Rohr, C. Lint (2015)
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene ExpressionPLoS Pathogens, 11
A. Hill, Daniel Rosenbloom, Feng Fu, M. Nowak, R. Siliciano (2014)
Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1Proceedings of the National Academy of Sciences, 111
S. Hansen, M. Piatak, A. Ventura, Colette Hughes, Roxanne Gilbride, Julia Ford, K. Oswald, R. Shoemaker, Yuan Li, Matthew Lewis, Awbrey Gilliam, Guangwu Xu, Nathan Whizin, B. Burwitz, Shannon Planer, John Turner, Alfred Legasse, M. Axthelm, J. Nelson, K. Früh, J. Sacha, J. Estes, B. Keele, P. Edlefsen, J. Lifson, L. Picker (2013)
Immune clearance of highly pathogenic SIV infectionNature, 502
S. Kalams, P. Goulder, A. Shea, N. Jones, A. Trocha, G. Ogg, B. Walker (1999)
Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral TherapyJournal of Virology, 73
B. Razooky, A. Pai, K. Aull, I. Rouzine, L. Weinberger (2015)
A Hardwired HIV Latency ProgramCell, 160
P. Paci, F. Martini, M. Bernaschi, G. D’Offizi, F. Castiglione (2011)
Timely HAART initiation may pave the way for a better viral controlBMC Infectious Diseases, 11
Qingsheng Li, P. Skinner, S. Ha, L. Duan, Teresa Mattila, Aaron Hage, C. White, D. Barber, L. O’Mara, P. Southern, C. Reilly, J. Carlis, C. Miller, R. Ahmed, A. Haase (2009)
Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral InfectionScience, 323
Shawn Blackburn, Haina Shin, W. Haining, Tao Zou, C. Workman, Antonio Polley, Michael Betts, Gordon Freeman, D. Vignali, E. Wherry (2009)
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infectionNature Immunology, 10
C. Day, D. Kaufmann, P. Kiepiela, Julia Brown, Eshia Moodley, S. Reddy, Elizabeth Mackey, Joseph Miller, A. Leslie, Chantal DePierres, Z. Mncube, Jaikumar Duraiswamy, Baogong Zhu, Q. Eichbaum, M. Altfeld, E. Wherry, H. Coovadia, P. Goulder, P. Goulder, P. Goulder, P. Klenerman, R. Ahmed, G. Freeman, B. Walker, B. Walker, B. Walker (2006)
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionNature, 443
A. Noto, Pearline Ngauv, L. Trautmann (2013)
Cell-based flow cytometry assay to measure cytotoxic activity.Journal of visualized experiments : JoVE, 82
D. Bolton, J. Minang, Matthew Trivett, Kaimei Song, Jennifer Tuscher, Yuan Li, M. Piatak, D. O’Connor, J. Lifson, M. Roederer, C. Ohlen (2009)
Trafficking, Persistence, and Activation State of Adoptively Transferred Allogeneic and Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones during Acute and Chronic Infection of Rhesus MacaquesThe Journal of Immunology, 184
Ginger Lehrman, Ian Hogue, S. Palmer, C. Jennings, C. Spina, A. Wiegand, A. Landay, R. Coombs, D. Richman, J. Mellors, J. Coffin, R. Bosch, D. Margolis (2005)
Depletion of latent HIV-1 infection in vivo: a proof-of-concept studyThe Lancet, 366
Y. Fukazawa, R. Lum, A. Okoye, Haesun Park, K. Matsuda, Jin Bae, S. Hagen, R. Shoemaker, C. Deleage, Carissa Lucero, D. Morcock, Tonya Swanson, Alfred Legasse, M. Axthelm, J. Hesselgesser, R. Geleziunas, V. Hirsch, P. Edlefsen, M. Piatak, J. Estes, J. Lifson, L. Picker (2014)
A B cell follicle sanctuary permits persistent productive SIV infection in elite controllersNature medicine, 21
J. Church (2015)
B Cell Follicle Sanctuary Permits Persistent Productive Simian Immunodeficiency Virus Infection in Elite ControllersPediatrics, 136
G. Mylvaganam, G. Silvestri, R. Amara (2015)
HIV therapeutic vaccines: moving towards a functional cure.Current opinion in immunology, 35
S. Migueles, K. Weeks, Eric Nou, Amy Berkley, Julia Rood, C. Osborne, C. Hallahan, N. Cogliano-Shutta, J. Metcalf, M. McLaughlin, Richard Kwan, J. Mican, R. Davey, M. Connors (2009)
Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral TherapyJournal of Virology, 83
Feng-xiang Wang, Yan Xu, J. Sullivan, Emily Souder, E. Argyris, E. Acheampong, Jaime Fisher, María Sierra, M. Thomson, R. Nájera, I. Frank, J. Kulkosky, R. Pomerantz, G. Nunnari (2005)
IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART.The Journal of clinical investigation, 115 1
Reports that lower T-cell immune activation prior to ART initiation is associated with delayed viral load rebound after ART interruption
P. Frange, A. Faye, V. Avettand-Fenoël, E. Bellaton, D. Descamps, M. Angin, A. David, S. Caillat-Zucman, G. Peytavin, C. Dollfus, J. chenadec, J. Warszawski, C. Rouzioux, A. Sáez-Cirión (2016)
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.The lancet. HIV, 3 1
M. Pace, E. Graf, L. Agosto, A. Mexas, Frances Male, Troy Brady, F. Bushman, U. O’Doherty (2012)
Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV LatencyPLoS Pathogens, 8
L. Janbazian, D. Price, Glenda Canderan, A. Filali‐Mouhim, Tedi Asher, D. Ambrozak, P. Scheinberg, M. Boulassel, J. Routy, R. Koup, D. Douek, R. Sékaly, L. Trautmann (2012)
Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic StimulationThe Journal of Immunology, 188
S. Hansen, Helen Wu, B. Burwitz, Colette Hughes, Katherine Hammond, A. Ventura, J. Reed, Roxanne Gilbride, Emily Ainslie, David Morrow, Julia Ford, Andrea Selseth, R. Pathak, D. Malouli, Alfred Legasse, M. Axthelm, J. Nelson, G. Gillespie, L. Walters, S. Brackenridge, H. Sharpe, Cesar López, K. Früh, B. Korber, A. McMichael, S. Gnanakaran, J. Sacha, L. Picker (2016)
Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex EScience, 351
J. Minang, E. Barsov, Fang Yuan, Matthew Trivett, M. Piatak, J. Lifson, D. Ott, C. Ohlen (2008)
Efficient inhibition of SIV replication in rhesus CD4+ T-cell clones by autologous immortalized SIV-specific CD8+ T-cell clones.Virology, 372 2
Annette Oxenius, David Price, Philippa Easterbrook, Christopher O’Callaghan, Anthony Kelleher, J. Whelan, Glenn Sontag, Andrew Sewell, Rodney Phillips (2000)
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America, 97 7
N. Restifo, M. Dudley, S. Rosenberg (2012)
Adoptive immunotherapy for cancer: harnessing the T cell responseNature Reviews Immunology, 12
M. Betts, A. Harari (2008)
Phenotype and function of protective T cell immune responses in HIVCurrent Opinion in HIV and AIDS, 3
R. Buckheit, R. Siliciano, J. Blankson (2013)
Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cellsRetrovirology, 10
K. Deng, M. Perțea, A. Rongvaux, Leyao Wang, C. Durand, G. Ghiaur, J. Lai, H. McHugh, Haiping Hao, Hao Zhang, J. Margolick, C. Gurer, A. Murphy, D. Valenzuela, G. Yancopoulos, S. Deeks, T. Strowig, Priti Kumar, J. Siliciano, S. Salzberg, R. Flavell, L. Shan, R. Siliciano (2015)
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutationsNature, 517
D. Persaud, H. Gay, C. Ziemniak, Y. Chen, M. Piatak, T. Chun, M. Strain, D. Richman, K. Luzuriaga (2013)
Absence of detectable HIV-1 viremia after treatment cessation in an infant.The New England journal of medicine, 369 19
C. Bullen, G. Laird, C. Durand, J. Siliciano, R. Siliciano, R. Siliciano (2014)
Novel ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivoNature medicine, 20
F. Hecht, Lei Wang, A. Collier, S. Little, M. Markowitz, J. Margolick, J. Kilby, E. Daar, B. Conway, S. Holte (2006)
A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection.The Journal of infectious diseases, 194 6
Laura Martins, Pawel Bonczkowski, A. Spivak, W. Spiegelaere, C. Novis, A. DePaula-Silva, E. Malatinkova, Wim Trypsteen, A. Bosque, L. Vanderkerckhove, V. Planelles (2016)
Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus.AIDS research and human retroviruses, 32 2
T. Henrich, Emily Hanhauser, F. Marty, M. Sirignano, S. Keating, Tzong-Hae Lee, Yvonne Robles, B. Davis, Jonathan Li, Andrea Heisey, A. Hill, M. Busch, P. Armand, R. Soiffer, M. Altfeld, D. Kuritzkes (2014)
Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell TransplantationAnnals of Internal Medicine, 161
L. Trautmann, F. Mbitikon-Kobo, J. Goulet, Yoav Peretz, Yu Shi, J. Grevenynghe, F. Procopio, M. Boulassel, J. Routy, N. Chomont, E. Haddad, R. Sékaly (2012)
Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection.Blood, 120 17
L. Hocqueloux, A. Sáez-Cirión, Christine Rouzioux (2013)
Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion.JAMA internal medicine, 173 6
E. Connick, Teresa Mattila, J. Folkvord, R. Schlichtemeier, Amie Meditz, M. Ray, M. McCarter, S. MaWhinney, Aaron Hage, C. White, P. Skinner (2007)
CTL Fail to Accumulate at Sites of HIV-1 Replication in Lymphoid Tissue12The Journal of Immunology, 178
Hongbing Yang, Hao Wu, G. Hancock, G. Clutton, N. Sande, Xiaoning Xu, Hui‐ping Yan, Xiaojie Huang, B. Angus, K. Kuldanek, S. Fidler, T. Denny, J. Birks, A. McMichael, L. Dorrell (2012)
Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection.The Journal of infectious diseases, 206 4
J. Whitney, A. Hill, Srisowmya Sanisetty, P. Penaloza-MacMaster, Jinyan Liu, Mayuri Shetty, Lily Parenteau, Crystal Cabral, Jennifer Shields, S. Blackmore, Jeffrey Smith, Amanda Brinkman, L. Peter, Sheeba Mathew, Kaitlin Smith, E. Borducchi, Daniel Rosenbloom, M. Lewis, J. Hattersley, Bei Li, J. Hesselgesser, R. Geleziunas, M. Robb, Jerome Kim, N. Michael, D. Barouch (2014)
Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus MonkeysNature, 512
G. Carcelain, B. Autran (2013)
Immune interventions in HIV infectionImmunological Reviews, 254
Graham Ogg, Xia Jin, Sebastian Bonhoeffer, Paul Moss, Martin Nowak, Simon Monard, Jeremy Segal, Yun-zhen Cao, Sarah Rowland-Jones, A. Hurley, M. Markowitz, David Ho, Andrew McMichael, Douglas Nixon (1999)
Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral TherapyJournal of Virology, 73
I. Rouzine, Ariel Weinberger, L. Weinberger (2015)
An Evolutionary Role for HIV Latency in Enhancing Viral TransmissionCell, 160
A. Perelson, R. Ribeiro (2013)
Modeling the within-host dynamics of HIV infectionBMC Biology, 11
(2016)
Repeated TLR7 agonist treatment of SIVþ monkeys on ART can lead to viral remission
Hocqueloux (2010)
Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infectionAIDS, 24
Z. Ndhlovu, Philomena Kamya, N. Mewalal, H. Kløverpris, T. Nkosi, Karyn Pretorius, F. Laher, Funsho Ogunshola, D. Chopera, K. Shekhar, M. Ghebremichael, N. Ismail, A. Moodley, A. Malik, A. Leslie, P. Goulder, S. Buus, A. Chakraborty, K. Dong, T. Ndung’u, B. Walker (2015)
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.Immunity, 43 3
Erika Lee, Feng Yue, Richard Jones, Calvin Lo, P. Sheth, Martin Hyrcza, Colin Kovacs, E. Benko, Rupert Kaul, Mario Ostrowski (2010)
The impact of CCL3L1 copy number in an HIV-1-infected white populationAIDS, 24
J. Casazza, M. Betts, L. Picker, R. Koup (2001)
Decay Kinetics of Human Immunodeficiency Virus-Specific CD8+ T Cells in Peripheral Blood after Initiation of Highly Active Antiretroviral TherapyJournal of Virology, 75
C. Cellerai, A. Harari, H. Stauss, S. Yerly, A. Geretti, A. Carroll, T. Yee, J. Ainsworth, I. Williams, J. Sweeney, A. Freedman, M. Johnson, G. Pantaleo, S. Loes (2011)
Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-ProgressorsPLoS ONE, 6
(2016)
Safety, immunologic and virologic activity of anti-PD-L1 in HIV-1 participants on ART. Boston: CROI2016; 2016
A. Spentzou, P. Bergin, D. Gill, H. Cheeseman, A. Ashraf, H. Kaltsidis, Michelle Cashin-Cox, Insiyah Anjarwalla, A. Steel, C. Higgs, A. Pozniak, A. Piechocka-Trocha, Johnson Wong, O. Anzala, E. Karita, L. Dally, F. Gotch, B. Walker, J. Gilmour, P. Hayes (2010)
Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates.The Journal of infectious diseases, 201 5
L. Shan, K. Deng, Neeta Shroff, C. Durand, S. Rabi, Hung‐Chih Yang, Hao Zhang, J. Margolick, J. Blankson, R. Siliciano, R. Siliciano (2012)
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.Immunity, 36 3
T. Chun, D. Engel, M. Berrey, T. Shea, L. Corey, A. Fauci (1998)
Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection.Proceedings of the National Academy of Sciences of the United States of America, 95 15
S. Crowe (2018)
Faculty of 1000 evaluation for The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.
Sogaard (2015)
The depsipeptide romidepsin reverses HIV-1 latency in vivoPLoS Pathog, 11
J. Petravic, Alexey Martyushev, J. Reece, S. Kent, M. Davenport (2014)
Modeling the Timing of Antilatency Drug Administration during HIV TreatmentJournal of Virology, 88
G. Hütter, D. Nowak, M. Mossner, S. Ganepola, A. Müssig, Kristina Allers, T. Schneider, J. Hofmann, C. Kücherer, O. Blau, I. Blau, W. Hofmann, E. Thiel (2009)
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.The New England journal of medicine, 360 7
A. Sáez-Cirión, So Shin, P. Versmisse, F. Barré-Sinoussi, G. Pancino (2010)
Ex vivo T cell–based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responsesNature Protocols, 5
Provides mathematical prediction on immune responses strength and HIV reservoir size to achieve posttreatment control after ART interruption
N. Archin, A. Liberty, A. Kashuba, S. Choudhary, J. Kuruc, A. Crooks, D. Parker, E. Anderson, M. Kearney, M. Strain, D. Richman, M. Hudgens, R. Bosch, J. Coffin, J. Eron, D. Hazuda, D. Margolis (2012)
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyNature, 487
M. Altfeld, E. Rosenberg, R. Shankarappa, J. Mukherjee, F. Hecht, Robert Eldridge, M. Addo, Samuel Poon, M. Phillips, G. Robbins, P. Sax, S. Boswell, J. Kahn, C. Brander, P. Goulder, J. Levy, J. Mullins, B. Walker (2001)
Cellular Immune Responses and Viral Diversity in Individuals Treated during Acute and Early HIV-1 InfectionThe Journal of Experimental Medicine, 193
L. Trautmann, L. Janbazian, N. Chomont, E. Said, S. Gimmig, B. Bessette, M. Boulassel, E. Delwart, H. Sepulveda, R. Balderas, J. Routy, E. Haddad, R. Sékaly (2006)
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionNature Medicine, 12
S. Hansen, J. Sacha, Colette Hughes, Julia Ford, B. Burwitz, Isabel Scholz, Roxanne Gilbride, Matthew Lewis, Awbrey Gilliam, A. Ventura, D. Malouli, Guangwu Xu, R. Richards, Nathan Whizin, J. Reed, Katherine Hammond, Miranda Fischer, John Turner, Alfred Legasse, M. Axthelm, P. Edlefsen, J. Nelson, J. Lifson, K. Früh, L. Picker (2013)
Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition ParadigmsScience, 340
M. Rothenberger, B. Keele, S. Wietgrefe, C. Fletcher, G. Beilman, J. Chipman, A. Khoruts, J. Estes, Jodi Anderson, Samuel Callisto, Thomas Schmidt, Ann Thorkelson, C. Reilly, K. Perkey, Thomas Reimann, N. Utay, Krystelle Makamdop, M. Stevenson, D. Douek, A. Haase, T. Schacker (2015)
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruptionProceedings of the National Academy of Sciences, 112
A. Yates, Frederik Graw, D. Barber, R. Ahmed, R. Regoes, R. Antia (2007)
Revisiting Estimates of CTL Killing Rates In VivoPLoS ONE, 2
W. Stöhr, S. Fidler, M. Mcclure, J. Weber, D. Cooper, G. Ramjee, P. Kaleebu, G. Tambussi, M. Schechter, A. Babiker, R. Phillips, K. Porter, J. Frater (2013)
Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on TherapyPLoS ONE, 8
S. Deeks (2012)
HIV: Shock and killNature, 487
B. Autran (2015)
Toward a cure for HIV—Seeking effective therapeutic vaccine strategiesEuropean Journal of Immunology, 45
Wang (2005)
IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAARTJ Clin Invest, 115
P. Borrow, H. Lewicki, B. Hahn, G. Shaw, M. Oldstone (1994)
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionJournal of Virology, 68
R. Jones, L. Ndhlovu, J. Barbour, P. Sheth, A. Jha, Brian Long, Jessica Wong, Malathy Satkunarajah, Marc Schweneker, J. Chapman, G. Gyenes, B. Vali, Martin Hyrcza, F. Yue, C. Kovacs, Aref Sassi, M. Loutfy, R. Halpenny, Desmond Persad, G. Spotts, F. Hecht, T. Chun, J. McCune, R. Kaul, James Rini, D. Nixon, M. Ostrowski (2008)
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionThe Journal of Experimental Medicine, 205
Clive Gray, Jody Lawrence, Jonathan Schapiro, J. Altman, John Altman, Mark Winters, Meg Crompton, M. Loi, S. Kundu, Mark Davis, T. Merigan (1999)
Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).Journal of immunology, 162 3
M. Perreau, A. Savoye, E. Crignis, J. Corpataux, R. Cubas, E. Haddad, L. Leval, C. Graziosi, G. Pantaleo (2013)
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionThe Journal of Experimental Medicine, 210
N. Chomont, M. El-Far, P. Ancuța, L. Trautmann, F. Procopio, B. Yassine-Diab, G. Boucher, M. Boulassel, G. Ghattas, J. Brenchley, T. Schacker, Brenna Hill, D. Douek, J. Routy, E. Haddad, R. Sékaly (2009)
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationNature Medicine, 15
Describes the ability of broad CD8 T-cell responses to clear HIV reservoir and provides the proof of concept that broad CD8 T cells need to be induced by immunobased strategies
J. Hurst, M. Hoffmann, M. Pace, James Williams, J. Thornhill, E. Hamlyn, J. Meyerowitz, C. Willberg, K. Koelsch, N. Robinson, Helen Brown, M. Fisher, S. Kinloch, D. Cooper, M. Schechter, G. Tambussi, S. Fidler, A. Babiker, J. Weber, A. Kelleher, R. Phillips, J. Frater (2015)
Immunological biomarkers predict HIV-1 viral rebound after treatment interruptionNature Communications, 6
P. Corbeau, J. Reynes (2011)
Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection.Blood, 117 21
J. Ananworanich, A. Schuetz, C. Vandergeeten, I. Sereti, M. Souza, R. Rerknimitr, R. Dewar, M. Marovich, F. Griensven, R. Sékaly, S. Pinyakorn, N. Phanuphak, R. Trichavaroj, Wiriya Rutvisuttinunt, N. Chomchey, R. Paris, S. Peel, V. Valcour, F. Maldarelli, N. Chomont, N. Michael, P. Phanuphak, Jerome Kim (2012)
Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV InfectionPLoS ONE, 7
A. Sáez-Cirión, C. Bacchus, L. Hocqueloux, V. Avettand-Fenoel, I. Girault, C. Lécuroux, V. Potard, P. Versmisse, A. Mélard, T. Prazuck, B. Descours, J. Guergnon, J. Viard, F. Boufassa, O. Lambotte, C. Goujard, L. Meyer, D. Costagliola, A. Venet, G. Pancino, B. Autran, C. Rouzioux (2013)
Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI StudyPLoS Pathogens, 9
V. Appay, D. Douek, D. Price (2008)
CD8+ T cell efficacy in vaccination and diseaseNature Medicine, 14
Nicola Smith, P. Mlcochova, S. Watters, M. Aasa-Chapman, N. Rabin, S. Moore, S. Edwards, J. Garson, P. Grant, R. Ferns, A. Kashuba, N. Mayor, J. Schellekens, S. Marsh, A. McMichael, A. Perelson, D. Pillay, N. Goonetilleke, Ravindra Gupta (2015)
Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In VivoClinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 61
(2016)
Virological remission after ART inter- ruption in African HIV-1 seroconverters
Purpose of review Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells (‘Shock and Kill’ strategy). Boosting potent HIV-specific CD8 + T cells is a promising way to achieve an HIV cure. Recent findings Recent studies provided the rationale for developing immune interventions to increase the numbers, function and location of HIV-specific CD8 + T cells to purge HIV reservoirs. Multiple approaches are being evaluated including very early suppression of HIV replication in acute infection, adoptive cell transfer, therapeutic vaccination or use of immunomodulatory molecules. New assays to measure the killing and antiviral function of induced HIV-specific CD8 + T cells have been developed to assess the efficacy of these new approaches. The strategies combining HIV reactivation and immunobased therapies to boost HIV-specific CD8 + T cells can be tested in in-vivo and in-silico models to accelerate the design of new clinical trials. Summary New immunobased strategies are explored to boost HIV-specific CD8 + T cells able to purge the HIV-infected cells with the ultimate goal of achieving spontaneous control of viral replication without antiretroviral treatment.
Current Opinion in HIV and AIDS – Wolters Kluwer Health
Published: Jul 1, 2016
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.