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Applied Immunohistochemistry & Molecular Morphology 9(2): 185–186, 2001 © 2001 Lippincott Williams & Wilkins, Inc., Philadelphia Letter to the Editors Ki67 Reactivity in Cell Membrane and Cytoplasm of Tonsil Crypt Epithelial Cells To the Editors: The unexpected finding of selective but nonspecific reactivities of monoclonal antibodies has been the sub- ject of several articles (1,2). Changes in epitope structure caused by fixation and the existence of short determi- nants shared by unrelated peptides and proteins have been pointed out, among others, as the possible sources of the anomalous reactions observed (1,3). In a recent article, Hirokawa and Carney (4) reported on the cell membrane and cytoplasmic reactivity for MIB-1, a well- FIG. 2. Epithelial cells of tonsil crypts showing strong re- known Ki67 monoclonal antibody, in hyalinizing trabec- activity for Ki88 in cell membranes and in slender cyto- ular adenoma of the thyroid gland, emphasizing its value plasmic prolongations. as a diagnostic tool in the differential diagnosis with papillary carcinoma. They also observed a faint reactiv- ity in the apical surface of some normal follicular cells. hour. Two avidin-biotin-peroxidase methods (Super Sen- Other normal tissues were not included in the study. sitive, Biogenex, and Vectastain, Vector, Burlingame, Recently, we
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jun 1, 2001
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