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Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Ki-67 Immunoreactivity in Type II Malformations of Cortical Development Richard A. Prayson, MD malorientation of neurons in a specific layer, and Abstract: Malformations of cortical development (MCD) are a morphologic alterations to neuronal cells. Although some well-recognized cause of chronic epilepsy. Most MCD are forms of malformation of cortical development seem defined by the neuronal component of the lesion and are to be focal in nature, as a group, they are generally considered to be relatively ‘‘static’’ lesions. Twenty-one cases of not considered neoplastic in nature and are, therefore, MCD type II (Taylor type cortical dysplasia) were retro- thought of as relatively static lesions that are present and spectively evaluated with Ki-67 antibody looking for evidence relatively unchanging from the time of their development. of cell proliferation and evaluating populations of cells that may The phenotypic spectrum of morphologic changes that be proliferating. Resections were from 13 males and 8 females are associated with this disorder is myriad and perhaps who ranged in age at the time of surgery from 6 weeks to 57 underscores our current lack of understanding regarding years (mean 8.6 y) and who had a duration
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jul 1, 2008
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