Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission Tomography Compared in Patients With Left Ventricular Dysfunction

Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission... Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission Tomography Compared in Patients With Left Ventricular Dysfunction Ichiro Matsunari, MD, PhD; Hirofumi Aoki, MD; Yusuke Nomura, MD, PhD; Nozomi Takeda, RN; Wei-Ping Chen, MD, PhD; Junichi Taki, MD, PhD; Kenichi Nakajima, MD, PhD; Stephan G. Nekolla, PhD; Seigo Kinuya, MD, PhD; Kouji Kajinami, MD, PhD 123 123 11 11 Background—Although both I-metaiodobenzylguanidine ( I-MIBG) imaging and C-hydroxyephedrine ( C-HED) positron emission tomography (PET) are used for assessing cardiac sympathetic innervation, their relationship remains unknown. The aims were to determine whether I-MIBG parameters such as heart-to-mediastinum ratio (H/M) are associated with quantitative measures by C-HED PET and to compare image quality, defect size, and location between 123 11 I-MIBG single-photon emission computed tomography (SPECT) and C-HED PET. Methods and Results—Twenty-one patients (mean left ventricular ejection fraction, 3915%) underwent I-MIBG imaging and C-HED PET. Early (15-minute), late (3-hour) H/M, and washout rate (WR) were calculated for 123 11 I-MIBG. Myocardial retention and WR was calculated for C-HED. Using a polar map approach, defect was defined as the area with relative activity 60% of the maximum. Both the early (r0.76) and late (r0.84) I-MIBG H/M 11 123 11 were correlated with C-HED retention. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission Tomography Compared in Patients With Left Ventricular Dysfunction

Kajinami, Kouji
Circulation: Cardiovascular Imaging , Volume 3 (5) – Sep 1, 2010
Download PDF
9 pages

Loading next page...
 
/lp/wolters-kluwer-health/iodine-123-metaiodobenzylguanidine-imaging-and-carbon-11-sFY0tOMAnj

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
© 2010 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.109.920538
pmid
20534790
Publisher site
See Article on Publisher Site

Abstract

Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission Tomography Compared in Patients With Left Ventricular Dysfunction Ichiro Matsunari, MD, PhD; Hirofumi Aoki, MD; Yusuke Nomura, MD, PhD; Nozomi Takeda, RN; Wei-Ping Chen, MD, PhD; Junichi Taki, MD, PhD; Kenichi Nakajima, MD, PhD; Stephan G. Nekolla, PhD; Seigo Kinuya, MD, PhD; Kouji Kajinami, MD, PhD 123 123 11 11 Background—Although both I-metaiodobenzylguanidine ( I-MIBG) imaging and C-hydroxyephedrine ( C-HED) positron emission tomography (PET) are used for assessing cardiac sympathetic innervation, their relationship remains unknown. The aims were to determine whether I-MIBG parameters such as heart-to-mediastinum ratio (H/M) are associated with quantitative measures by C-HED PET and to compare image quality, defect size, and location between 123 11 I-MIBG single-photon emission computed tomography (SPECT) and C-HED PET. Methods and Results—Twenty-one patients (mean left ventricular ejection fraction, 3915%) underwent I-MIBG imaging and C-HED PET. Early (15-minute), late (3-hour) H/M, and washout rate (WR) were calculated for 123 11 I-MIBG. Myocardial retention and WR was calculated for C-HED. Using a polar map approach, defect was defined as the area with relative activity 60% of the maximum. Both the early (r0.76) and late (r0.84) I-MIBG H/M 11 123 11 were correlated with C-HED retention.

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Sep 1, 2010

There are no references for this article.