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Intestinal Type and Endocervical-like Ovarian Mucinous Neoplasms are Immunophenotypically Distinct Entities

Intestinal Type and Endocervical-like Ovarian Mucinous Neoplasms are Immunophenotypically... RESEARCH ARTICLE Intestinal Type and Endocervical-like Ovarian Mucinous Neoplasms are Immunophenotypically Distinct Entities Xiaoqi Lin, MD, PhD,* Jennifer L. Lindner, DO,w Jan F. Silverman, MD,w and Yulin Liu, MDw rimary ovarian mucinous carcinoma constitutes ap- Abstract: Ovarian mucinous neoplasm (OMN) is traditionally Pproximately 10% of all primary ovarian malignant 1,2 classified as either intestinal type or endocervical-like subtypes. neoplasms. Traditionally ovarian mucinous neoplasm The 2 subtypes represent different clinicopathologic character- (OMN) is classified as benign, borderline, and carcinoma istics. The immunophenotype of the 2 subtypes has not been on the basis of the morphologic features of the lining adequately investigated. In this study, we investigated 14 epithelial cells and stromal invasion. Two subtypes, intestinal type OMNs (borderline and adenocarcinoma) and endocervical-like and intestinal type, have been described. 12 endocervical-like OMNs (borderline and adenocarcinoma) The 2 subtypes have different clinicopathologic charac- for their expression of PDX-1, CDX-2, CA-125, CK7, CK20, teristics. WT-1, D2-40, and TTF-1. We also included 15 colorectal The borderline intestinal type OMN accounts for adenocarcinomas metastatic in the ovary, as they may 85% to 90% of borderline OMNs with patients having a 2,4 occasionally mimic OMN. The intestinal type OMNs were mean age of 35 to 47 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Intestinal Type and Endocervical-like Ovarian Mucinous Neoplasms are Immunophenotypically Distinct Entities

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References (31)

ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181672574
pmid
18665037
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Intestinal Type and Endocervical-like Ovarian Mucinous Neoplasms are Immunophenotypically Distinct Entities Xiaoqi Lin, MD, PhD,* Jennifer L. Lindner, DO,w Jan F. Silverman, MD,w and Yulin Liu, MDw rimary ovarian mucinous carcinoma constitutes ap- Abstract: Ovarian mucinous neoplasm (OMN) is traditionally Pproximately 10% of all primary ovarian malignant 1,2 classified as either intestinal type or endocervical-like subtypes. neoplasms. Traditionally ovarian mucinous neoplasm The 2 subtypes represent different clinicopathologic character- (OMN) is classified as benign, borderline, and carcinoma istics. The immunophenotype of the 2 subtypes has not been on the basis of the morphologic features of the lining adequately investigated. In this study, we investigated 14 epithelial cells and stromal invasion. Two subtypes, intestinal type OMNs (borderline and adenocarcinoma) and endocervical-like and intestinal type, have been described. 12 endocervical-like OMNs (borderline and adenocarcinoma) The 2 subtypes have different clinicopathologic charac- for their expression of PDX-1, CDX-2, CA-125, CK7, CK20, teristics. WT-1, D2-40, and TTF-1. We also included 15 colorectal The borderline intestinal type OMN accounts for adenocarcinomas metastatic in the ovary, as they may 85% to 90% of borderline OMNs with patients having a 2,4 occasionally mimic OMN. The intestinal type OMNs were mean age of 35 to 47

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Oct 1, 2008

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