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ORIGINAL ARTICLE Interobserver Variability in Histologic Recognition, Interpretation of KIT Immunostaining, and Determining MIB-1 Labeling Indices in Gastrointestinal Stromal Tumors and Other Spindle Cell Tumors of the Gastrointestinal Tract Umio Yamaguchi, MD,* Tadashi Hasegawa, MD, PhD,* Shinji Sakurai, MD, PhD,w Yuji Sakuma, MD,w Yutaka Takazawa, MD, PhD,z Tsunekazu Hishima, MD, PhD,y Tomoko Mitsuhashi, MD, PhD,z Shigeki Sekine, MD, PhD,* Hirokazu Chuman, MD, PhD,* and Tadakazu Shimoda, MD, PhD* KIT, CD34, desmin, SMA, and S-100 protein. Although there Abstract: The authors studied the concordance among seven is clearly unavoidable inter-observer and interlaboratory varia- pathologists for the histologic diagnosis, interpretation of KIT bility in the interpretation of KIT immunostained sections and immunostaining, and determining MIB-1 labeling indices (LI) in interobserver variability in the determination of MIB-1 LI, the 80 adult patients with primary spindle cell tumors, mainly of the concordance between observes is very acceptable, and in most gastrointestinal tract, mesentery, retroperitoneum, and pelvis, instances such variability can be eliminated by careful reviewing based on the review of tissue sections using an immunohisto- of the hematoxylin and eosin and immunostained sections. chemical panel of antibodies for KIT/CD117, CD34, desmin, Key Words: gastrointestinal stromal tumors (GISTs), spindle smooth muscle actin (SMA), and
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2006
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