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Editorial Have We Found the Right One to Block? Are Cardiovascular Effects of Biologic Therapies Similar? Ayman Samman Tahhan, MD; Pratik B. Sandesara, MD; Arshed A. Quyyumi, MD here is strong experimental and clinical support for a recognized. However, randomized controlled trials with Tcausal role of immune dysregulation and inflammation in TNF-α antagonists were disappointing and associated with atherosclerosis and heart failure. Atherosclerotic lesions are increased risk in heart failure. Novel therapies targeted infiltrated by monocytes, macrophages, and T lymphocytes against specific cytokines in the inflammatory cascade, such (predominantly Th1). Cytokines, including interleukin-6 (IL- as IL-12, are currently under investigation for treatment 6) and tumor necrosis factor-α (TNF-α), are released by the of a variety of disorders. Ustekinumab is one of the several infiltrating inflammatory cells and stimulate adhesion mol- human monoclonal antibodies targeting the subunit (p40) of ecule expression. IL-6 can downregulate nitric oxide produc- IL-12 and IL-23 that was approved by the Food and Drug tion and further worsen endothelial dysfunction. Progression Administration in 2009 for treatment of psoriasis. Recent data of this inflammatory response is primarily regulated by spe- suggest that Ustekinumab may improve psoriasis by inhibit- cific patterns of cytokine expression. Interleukin 12 (IL-12) ing
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Sep 1, 2017
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