Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Intake of Red Wine Increases the Number and Functional Capacity of Circulating Endothelial Progenitor Cells by Enhancing Nitric Oxide Bioavailability

Intake of Red Wine Increases the Number and Functional Capacity of Circulating Endothelial... Clinical and Population Studies Intake of Red Wine Increases the Number and Functional Capacity of Circulating Endothelial Progenitor Cells by Enhancing Nitric Oxide Bioavailability Po-Hsun Huang, Yung-Hsiang Chen, Hsiao-Ya Tsai, Jia-Shiong Chen, Tao-Cheng Wu, Feng-Yen Lin, Masataka Sata, Jaw-Wen Chen, Shing-Jong Lin Objective—Red wine (RW) consumption has been associated with a reduction of cardiovascular events, but limited data are available on potential mediating mechanisms. This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability. Methods and Results—Eighty healthy, young subjects were randomized and assigned to consume water (100 mL), RW (100 mL), beer (250 mL), or vodka (30 mL) daily for 3 weeks. Flow cytometry was used to quantify circulating EPC numbers, and in vitro assays were used to evaluate EPC functions. After RW ingestion, endothelial function determined by flow-mediated vasodilation was significantly enhanced; however, it remained unchanged after water, beer, or vodka intake. There were significantly increased numbers of circulating EPC (defined as KDR CD133 , CD34 CD133 , CD34 KDR ) and EPC colony-forming units only in the RW group (all P0.05). Only RW ingestion significantly enhanced plasma levels of nitric http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

Intake of Red Wine Increases the Number and Functional Capacity of Circulating Endothelial Progenitor Cells by Enhancing Nitric Oxide Bioavailability

Loading next page...
 
/lp/wolters-kluwer-health/intake-of-red-wine-increases-the-number-and-functional-capacity-of-QaMWZorJAf
ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.109.200618
pmid
20093623

Abstract

Clinical and Population Studies Intake of Red Wine Increases the Number and Functional Capacity of Circulating Endothelial Progenitor Cells by Enhancing Nitric Oxide Bioavailability Po-Hsun Huang, Yung-Hsiang Chen, Hsiao-Ya Tsai, Jia-Shiong Chen, Tao-Cheng Wu, Feng-Yen Lin, Masataka Sata, Jaw-Wen Chen, Shing-Jong Lin Objective—Red wine (RW) consumption has been associated with a reduction of cardiovascular events, but limited data are available on potential mediating mechanisms. This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability. Methods and Results—Eighty healthy, young subjects were randomized and assigned to consume water (100 mL), RW (100 mL), beer (250 mL), or vodka (30 mL) daily for 3 weeks. Flow cytometry was used to quantify circulating EPC numbers, and in vitro assays were used to evaluate EPC functions. After RW ingestion, endothelial function determined by flow-mediated vasodilation was significantly enhanced; however, it remained unchanged after water, beer, or vodka intake. There were significantly increased numbers of circulating EPC (defined as KDR CD133 , CD34 CD133 , CD34 KDR ) and EPC colony-forming units only in the RW group (all P0.05). Only RW ingestion significantly enhanced plasma levels of nitric

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Apr 1, 2010

There are no references for this article.