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(2002)
Copyright #ERS Journals Ltd 2002 European Respiratory Journal
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Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease Jay A. Nadel Abbreviations Purpose of review Airway epithelial surface signaling is provided by epidermal DUOX1 dual oxidase-1 EGFR epidermal growth factor receptor growth factor receptor (EGFR) phosphorylation, resulting in GPCR G protein coupled receptor innate immune responses. Here the focus is the EGFR LPS lipopolysaccharide ROS reactive oxygen species cascades leading to immune mucin responses. The review TACE tumor necrosis factor alpha-converting enzyme is timely because recent discoveries implicate these TGF transforming growth factor pathways in multiple innate immune defenses in addition to mucin production. 2007 Lippincott Williams & Wilkins 1528-4050 Recent findings EGFR activation causes mucin production and inhibition prevents mucin production by multiple stimuli. The Introduction receptors and their epithelial-bound proligands are During evolution, when animals migrated from the sea to examined. Proteases cleave and release soluble ligand, land, the respiratory exchange apparatus was moved from which then activates EGFR. A surface metalloprotease, gills (in direct contact with the environment) to the thoracic tumor necrosis factor alpha-converting enzyme (TACE), cavity (where the lungs are in close contact with the modulates proligand release (and thus EGFR activation). circulation). Communication with the environment was TACE
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Feb 1, 2007
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