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Incremental Prognostic Value of Myocardial Perfusion Imaging in Patients Referred to Stress Single-Photon Emission Computed Tomography With Renal Dysfunction

Incremental Prognostic Value of Myocardial Perfusion Imaging in Patients Referred to Stress... Original Articles Incremental Prognostic Value of Myocardial Perfusion Imaging in Patients Referred to Stress Single-Photon Emission Computed Tomography With Renal Dysfunction Mouaz H. Al-Mallah, MD, MSc; Rory Hachamovitch, MD, MSc; Sharmila Dorbala, MBBS; Marcelo F. Di Carli, MD Background—Coronary artery disease is the main cause of mortality and morbidity in patients with impaired renal function. The aim of this study was to evaluate the prognostic implications of single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in patients with impaired renal function. Methods and Results—We included 7348 consecutive patients (mean age, 6413 years; 51% men) referred for SPECT-MPI between March 2002 and October 2006. Renal function was estimated using the estimated glomerular filtration rate formula. Patients were followed up for the incidence of all-cause mortality. Patients with decreased glomerular filtration rate were more often older, with higher prevalence of conventional risk factors (P0.001). After a median follow-up of 2.6 years (25th to 75th percentiles, 1.5 to 3.7), 693 (9.4%) patients died. The risk of death increased with worsening kidney function. At each stage of impaired renal function, patients with abnormal SPECT-MPI had increased hazard of adverse events (P0.0001). Using Cox proportional hazards analysis, the magnitude of total perfusion deficit and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Incremental Prognostic Value of Myocardial Perfusion Imaging in Patients Referred to Stress Single-Photon Emission Computed Tomography With Renal Dysfunction

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ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.108.831164
pmid
19920040
Publisher site
See Article on Publisher Site

Abstract

Original Articles Incremental Prognostic Value of Myocardial Perfusion Imaging in Patients Referred to Stress Single-Photon Emission Computed Tomography With Renal Dysfunction Mouaz H. Al-Mallah, MD, MSc; Rory Hachamovitch, MD, MSc; Sharmila Dorbala, MBBS; Marcelo F. Di Carli, MD Background—Coronary artery disease is the main cause of mortality and morbidity in patients with impaired renal function. The aim of this study was to evaluate the prognostic implications of single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in patients with impaired renal function. Methods and Results—We included 7348 consecutive patients (mean age, 6413 years; 51% men) referred for SPECT-MPI between March 2002 and October 2006. Renal function was estimated using the estimated glomerular filtration rate formula. Patients were followed up for the incidence of all-cause mortality. Patients with decreased glomerular filtration rate were more often older, with higher prevalence of conventional risk factors (P0.001). After a median follow-up of 2.6 years (25th to 75th percentiles, 1.5 to 3.7), 693 (9.4%) patients died. The risk of death increased with worsening kidney function. At each stage of impaired renal function, patients with abnormal SPECT-MPI had increased hazard of adverse events (P0.0001). Using Cox proportional hazards analysis, the magnitude of total perfusion deficit and

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Nov 1, 2009

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