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In Vivo NMR Imaging of Sodium‐23 in the Human Head

In Vivo NMR Imaging of Sodium‐23 in the Human Head Surgicale report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium, shows a greater vriation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300–400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased “NMR visibility” of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive menas for early detection of some brain disorders than other imaging methods. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Computer Assisted Tomography Wolters Kluwer Health

In Vivo NMR Imaging of Sodium‐23 in the Human Head

Mun, S. K.
Journal of Computer Assisted Tomography , Volume 9 (1) – Jan 1, 1985
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ISSN
0363-8715
eISSN
1532-3145

Abstract

Surgicale report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium, shows a greater vriation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300–400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased “NMR visibility” of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive menas for early detection of some brain disorders than other imaging methods.

Journal

Journal of Computer Assisted Tomography – Wolters Kluwer Health

Published: Jan 1, 1985

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