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In-vivo confocal microscopy of the ocular surface ocular allergy and dry eye

In-vivo confocal microscopy of the ocular surface ocular allergy and dry eye REVIEW URRENT In-vivo confocal microscopy of the ocular surface: PINION ocular allergy and dry eye a,b,c d a,b Edoardo Villani , Flavio Mantelli , and Paolo Nucci Purpose of review To summarize recent studies on in-vivo confocal microscopy (IVCM) findings in ocular allergy and dry eye disease (DED), highlighting the role of IVCM in the advancement of knowledge of these diseases. Recent findings IVCM provided new data on ocular surface changes in both ocular allergy and DED. Corneal and conjunctival epithelial and inflammatory cells, corneal nerves, and Meibomian glands showed peculiar patterns of abnormalities, not easily discernable with current clinical exams in these two diseases and their subtypes. At present, small sample size of researches, and poor standardization and evidence of image analysis and interpretation are the most challenging issues. Summary Ocular allergy and DED are common and increasing healthcare problems, and need better understanding of pathogenesis and natural history, more reliable endpoints, and more tailored diagnostic and therapeutic approaches. IVCM allows quick, noninvasive, steady-state respectful examination of the ocular surface at cellular level to be performed and has potential to be used in the future as a biomarker and to contribute to optimize the tailored management of these http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

In-vivo confocal microscopy of the ocular surface ocular allergy and dry eye

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Copyright
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e328364ec92
pmid
23974688
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT In-vivo confocal microscopy of the ocular surface: PINION ocular allergy and dry eye a,b,c d a,b Edoardo Villani , Flavio Mantelli , and Paolo Nucci Purpose of review To summarize recent studies on in-vivo confocal microscopy (IVCM) findings in ocular allergy and dry eye disease (DED), highlighting the role of IVCM in the advancement of knowledge of these diseases. Recent findings IVCM provided new data on ocular surface changes in both ocular allergy and DED. Corneal and conjunctival epithelial and inflammatory cells, corneal nerves, and Meibomian glands showed peculiar patterns of abnormalities, not easily discernable with current clinical exams in these two diseases and their subtypes. At present, small sample size of researches, and poor standardization and evidence of image analysis and interpretation are the most challenging issues. Summary Ocular allergy and DED are common and increasing healthcare problems, and need better understanding of pathogenesis and natural history, more reliable endpoints, and more tailored diagnostic and therapeutic approaches. IVCM allows quick, noninvasive, steady-state respectful examination of the ocular surface at cellular level to be performed and has potential to be used in the future as a biomarker and to contribute to optimize the tailored management of these

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Oct 1, 2013

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