Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Improvements in antiretroviral therapy outcomes over calendar time

Improvements in antiretroviral therapy outcomes over calendar time Improvements in antiretroviral therapy outcomes over calendar time Mark A. Boyd National Centre in HIV Epidemiology and Clinical Purpose of review Research, University of New South Wales, Sydney, The introduction of combination antiretroviral therapy (cART) led to substantial New South Wales, Australia reductions in HIV-associated morbidity and mortality. However, the regimens in the early Correspondence to Mark A. Boyd, MD, FRACP, cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria combinations and novel strategies for cART delivery such as ritonavir ‘boosting’ of HIV- Street, Sydney, NSW 2010, Australia protease inhibitors have led to a perception of improvements in the tolerability and Tel: +61 2 9385 0900; fax: +61 2 9385 0910; e-mail: mboyd@nchecr.unsw.edu.au durability of contemporary cART regimens. It is in turn assumed that these developments have led to improved outcomes in the latter era of cART. Current Opinion in HIV and AIDS 2009, 4:194–199 Recent findings Both cohort studies and randomized clinical trials suggest improvements in cART outcomes over calendar time. Key associated factors include reduced pill burden and dosing interval and improved tolerability and reduced toxicity of newer http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Improvements in antiretroviral therapy outcomes over calendar time

Boyd, Mark A
Current Opinion in HIV and Aids , Volume 4 (3) – May 1, 2009
Download PDF
6 pages

Loading next page...
 
/lp/wolters-kluwer-health/improvements-in-antiretroviral-therapy-outcomes-over-calendar-time-wGk29o4QUf

References (50)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328329fc8d
pmid
19532050
Publisher site
See Article on Publisher Site

Abstract

Improvements in antiretroviral therapy outcomes over calendar time Mark A. Boyd National Centre in HIV Epidemiology and Clinical Purpose of review Research, University of New South Wales, Sydney, The introduction of combination antiretroviral therapy (cART) led to substantial New South Wales, Australia reductions in HIV-associated morbidity and mortality. However, the regimens in the early Correspondence to Mark A. Boyd, MD, FRACP, cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria combinations and novel strategies for cART delivery such as ritonavir ‘boosting’ of HIV- Street, Sydney, NSW 2010, Australia protease inhibitors have led to a perception of improvements in the tolerability and Tel: +61 2 9385 0900; fax: +61 2 9385 0910; e-mail: mboyd@nchecr.unsw.edu.au durability of contemporary cART regimens. It is in turn assumed that these developments have led to improved outcomes in the latter era of cART. Current Opinion in HIV and AIDS 2009, 4:194–199 Recent findings Both cohort studies and randomized clinical trials suggest improvements in cART outcomes over calendar time. Key associated factors include reduced pill burden and dosing interval and improved tolerability and reduced toxicity of newer

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2009

There are no references for this article.