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Immunology of infants through adolescents: responses to emulate for HIV vaccines

Immunology of infants through adolescents: responses to emulate for HIV vaccines Immunology of infants through adolescents: responses to emulate for HIV vaccines a,b a,b Heather B. Jaspan and Willem A. Hanekom Purpose of review Introduction The major target groups for an HIV vaccine include Human immunodeficiency virus (HIV) has had devastat- breastfeeding infants and adolescents. Differential immune ing consequences, with an estimated 4.3 million infec- maturity in these age groups may significantly impact tions worldwide, 2.3 million of which are in children vaccine efficacy, and should be taken into account when under the age of 15 years [1]. The search for a successful developing vaccines. Here we review these differences, vaccine against HIV is a global priority, and many prom- with an emphasis on the immune response to vaccines for ising candidates are in development or in clinical HIV and other pathogens. Recommendations for potential trials (websites: http://www.iavi.org; http://chi.ucsf.edu/ adaptation of current HIV vaccines are also made. vaccines). Important target populations for an HIV Recent findings vaccine include breastfeeding infants and adolescents An effective neonatal vaccine needs to be immunogenic in before the onset of sexual activity. Vaccine development the presence of maternal antibody, and must induce efforts, however, have focused mainly on adults. No trials cytotoxic T-lymphocyte responses, neutralizing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Immunology of infants through adolescents: responses to emulate for HIV vaccines

Hanekom, Willem A
Current Opinion in HIV and Aids , Volume 2 (5) – Sep 1, 2007
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References (107)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3282e1c633
pmid
19372917
Publisher site
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Abstract

Immunology of infants through adolescents: responses to emulate for HIV vaccines a,b a,b Heather B. Jaspan and Willem A. Hanekom Purpose of review Introduction The major target groups for an HIV vaccine include Human immunodeficiency virus (HIV) has had devastat- breastfeeding infants and adolescents. Differential immune ing consequences, with an estimated 4.3 million infec- maturity in these age groups may significantly impact tions worldwide, 2.3 million of which are in children vaccine efficacy, and should be taken into account when under the age of 15 years [1]. The search for a successful developing vaccines. Here we review these differences, vaccine against HIV is a global priority, and many prom- with an emphasis on the immune response to vaccines for ising candidates are in development or in clinical HIV and other pathogens. Recommendations for potential trials (websites: http://www.iavi.org; http://chi.ucsf.edu/ adaptation of current HIV vaccines are also made. vaccines). Important target populations for an HIV Recent findings vaccine include breastfeeding infants and adolescents An effective neonatal vaccine needs to be immunogenic in before the onset of sexual activity. Vaccine development the presence of maternal antibody, and must induce efforts, however, have focused mainly on adults. No trials cytotoxic T-lymphocyte responses, neutralizing

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Sep 1, 2007

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