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Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic... RESEARCH ARTICLE Immunolocalization of b-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands Marisa C. L. S. Genelhu, PhD,*w z Helenice Gobbi, PhD,w Diele C. B. Arantes, PhD,y Sergio V. Cardoso, PhD,J and Geovanni D. Cassali, PhD*w transmembrane glycoproteins, located in adherent Abstract: b-catenin plays a central role in cadherin/catenin cell- junctions. Adhesion occurs through homotypical bind- cell adhesion complex and is involved in cell signaling pathway. ings between their extracellular amino-terminal domains. Change in b-catenin distribution has been associated with Nevertheless, by means of its cytoplasmic carboxy- several human cancers including salivary gland tumors. We terminal tail, E-cadherin is linked to a series of actinic studied the immunolocalization of b-catenin in a series of microfilaments of cell cytoskeleton through a-catenins, pleomorphic adenomas (PA) and carcinomas ex-pleomorphic b-catenins, g-catenins and p120. adenomas (Ca ex-PA). Ten samples of PA and ten of Ca ex-PA In addition to its well-defined role in regulating cell- were evaluated by immunohistochemistry using streptavidin- cell adhesion via interactions with E-cadherin, b-catenin, biotin-peroxidase technique and a monoclonal antibody against a 92-kd protein, has a critical role in the highly conserved 6,7 b-catenin (E-5). Cell membrane/cytoplasmic staining of Wnt (Wingless) signaling pathway. When b-catenin b-catenin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

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ISSN
1541-2016
DOI
10.1097/01.pai.0000213123.04215.95
pmid
17721271
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Immunolocalization of b-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands Marisa C. L. S. Genelhu, PhD,*w z Helenice Gobbi, PhD,w Diele C. B. Arantes, PhD,y Sergio V. Cardoso, PhD,J and Geovanni D. Cassali, PhD*w transmembrane glycoproteins, located in adherent Abstract: b-catenin plays a central role in cadherin/catenin cell- junctions. Adhesion occurs through homotypical bind- cell adhesion complex and is involved in cell signaling pathway. ings between their extracellular amino-terminal domains. Change in b-catenin distribution has been associated with Nevertheless, by means of its cytoplasmic carboxy- several human cancers including salivary gland tumors. We terminal tail, E-cadherin is linked to a series of actinic studied the immunolocalization of b-catenin in a series of microfilaments of cell cytoskeleton through a-catenins, pleomorphic adenomas (PA) and carcinomas ex-pleomorphic b-catenins, g-catenins and p120. adenomas (Ca ex-PA). Ten samples of PA and ten of Ca ex-PA In addition to its well-defined role in regulating cell- were evaluated by immunohistochemistry using streptavidin- cell adhesion via interactions with E-cadherin, b-catenin, biotin-peroxidase technique and a monoclonal antibody against a 92-kd protein, has a critical role in the highly conserved 6,7 b-catenin (E-5). Cell membrane/cytoplasmic staining of Wnt (Wingless) signaling pathway. When b-catenin b-catenin

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Sep 1, 2007

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