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REVIEW ARTICLE Immunohistochemistry as a Surrogate for Molecular Testing: A Review Paul E. Swanson, MD t can be argued that immunohistochemistry (IHC) is Abstract: Despite the myriad of genetic and epigenetic alter- Ifundamentally a surrogate testing modality. The pres- ations in human neoplasms that seem to demand specific mo- ence of most known targets of IHC, either proteins or lecular probes for their identification and practical application peptide-containing complex mucoproteins, lipoproteins, to diagnostic pathology, immunohistochemistry (IHC) remains and glycoproteins, is rarely known with certainty; rather, a vital component of laboratory testing in the emerging molec- presence is inferred from the assumed relationship be- ular era. The development and proper application of sensitive tween an immunogen and the antibodies it induces. and specific antibodies raised against cryptic proteins only ex- Knowing that the immunogen is often selected based on pressed in quantity after gene translocation, translocation-spe- an ex vivo characterization of the native peptide and that cific chimeric fusion peptides, and gene products overexpressed documentation of appropriate avidity and affinity of the because of gene amplification demonstrate that IHC is a legit- antibody for that peptide is also often evaluated in a imate surrogate for traditional cytogenetic and in situ
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Feb 1, 2015
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