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Immunohistochemical Profiling of Wilms Tumor A Tissue Microarray Study

Immunohistochemical Profiling of Wilms Tumor A Tissue Microarray Study RESEARCH ARTICLE Immunohistochemical Profiling of Wilms Tumor A Tissue Microarray Study Mohammad Vasei, MD,* Holger Moch, MD,w Abdollah Mousavi, MD,* Abdol Mohammad Kajbafzadeh, MD,z and Guido Sauter, MDy ilms tumor (WT) is the most common embryonic Aim: Wilms tumor (WT) usually shows a bi-phasic or tri-phasic Wtumor of the kidney. WT usually presents a morphology comprised of blastemal, stromal, and epithelial triphasic pattern, comprised of blastemal, stromal, and cells. Other biphasic renal tumors that can mimic WT may pose epithelial cell types, but biphasic and monophasic lesions diagnostic dilemmas especially in preoperative needle biopsy are often observed. Each histologic component may show samples. This tissue microarray study was designed to investi- a wide range of cell types and patterns. This heterogeneity gate the immunohistochemical features that may prove useful in manifests also at the molecular level and is more 1,2 the accurate diagnosis of WT in small biopsy samples. prominent in the blastemal component. Other distinct but rare renal tumors, composed of Methods: Eight punches from each paraffin block of 45 cases of stromal and epithelial elements, include metanephric WTs were used to construct 5 tissue microarray blocks. adenofibroma (MAF), mixed epithelial and stromal Immunohistochemical reactions of blastemal, stromal, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Immunohistochemical Profiling of Wilms Tumor A Tissue Microarray Study

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31804d6825
pmid
18227731
Publisher site
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Abstract

RESEARCH ARTICLE Immunohistochemical Profiling of Wilms Tumor A Tissue Microarray Study Mohammad Vasei, MD,* Holger Moch, MD,w Abdollah Mousavi, MD,* Abdol Mohammad Kajbafzadeh, MD,z and Guido Sauter, MDy ilms tumor (WT) is the most common embryonic Aim: Wilms tumor (WT) usually shows a bi-phasic or tri-phasic Wtumor of the kidney. WT usually presents a morphology comprised of blastemal, stromal, and epithelial triphasic pattern, comprised of blastemal, stromal, and cells. Other biphasic renal tumors that can mimic WT may pose epithelial cell types, but biphasic and monophasic lesions diagnostic dilemmas especially in preoperative needle biopsy are often observed. Each histologic component may show samples. This tissue microarray study was designed to investi- a wide range of cell types and patterns. This heterogeneity gate the immunohistochemical features that may prove useful in manifests also at the molecular level and is more 1,2 the accurate diagnosis of WT in small biopsy samples. prominent in the blastemal component. Other distinct but rare renal tumors, composed of Methods: Eight punches from each paraffin block of 45 cases of stromal and epithelial elements, include metanephric WTs were used to construct 5 tissue microarray blocks. adenofibroma (MAF), mixed epithelial and stromal Immunohistochemical reactions of blastemal, stromal,

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2008

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