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Immunohistochemical Localization of Interleukin-6 in Human Pancreatitis

Immunohistochemical Localization of Interleukin-6 in Human Pancreatitis RESEARCH ARTICLE Immunohistochemical Localization of Interleukin-6 in Human Pancreatitis Monika Jablonowska, PhD,* Halina Milnerowicz, PhD,* Jerzy Rabczynski, PhD,w Stanislaw Milnerowicz, PhD,z Stanislaw Nabzdyk, PhD,z Dariusz Patrzalek, PhD,y and Artur Milnerowicz, PhDy stages. Of the many agents examined, increased levels of Abstract: The aim of the study was to identify immunohisto- C-reactive protein (CRP), polymorphonuclear elastase chemically the localization of interleukin (IL)-6 in normal activity, adhesion molecules and interleukin-6 (IL-6) most 3–7 pancreas and in chronic pancreatitis (CP). Samples of tissues of reliably predict complicated cases. normal pancreas (n = 5) and CP (n = 16), were verified IL-6 is a 22 to 30-kd glycoprotein produced by a histopathologically and then IL-6 was localized by immunohis- wide range of cells including activated T-lymphocytes tochemical staining using the monoclonal antihuman IL-6 monocytes/macrophages, endothelial cells, fibroblasts, antibody and test LSAB2-HRP to visualize IL-6/Ab complexes. smooth muscle cells in response to stimulation by In slices of the pancreas, derived from patients with CP, a much endotoxin, IL-1, tumor necrosis factor-a and has a wide stronger immunohistochemical reaction was noticed as com- variety of biologic, differentiation, and growth-promoting pared with controls specimens. IL-6 was localized in exocrine, 8,9 effects in a variety of target http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Immunohistochemical Localization of Interleukin-6 in Human Pancreatitis

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e318031ffe8
pmid
18091322
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Immunohistochemical Localization of Interleukin-6 in Human Pancreatitis Monika Jablonowska, PhD,* Halina Milnerowicz, PhD,* Jerzy Rabczynski, PhD,w Stanislaw Milnerowicz, PhD,z Stanislaw Nabzdyk, PhD,z Dariusz Patrzalek, PhD,y and Artur Milnerowicz, PhDy stages. Of the many agents examined, increased levels of Abstract: The aim of the study was to identify immunohisto- C-reactive protein (CRP), polymorphonuclear elastase chemically the localization of interleukin (IL)-6 in normal activity, adhesion molecules and interleukin-6 (IL-6) most 3–7 pancreas and in chronic pancreatitis (CP). Samples of tissues of reliably predict complicated cases. normal pancreas (n = 5) and CP (n = 16), were verified IL-6 is a 22 to 30-kd glycoprotein produced by a histopathologically and then IL-6 was localized by immunohis- wide range of cells including activated T-lymphocytes tochemical staining using the monoclonal antihuman IL-6 monocytes/macrophages, endothelial cells, fibroblasts, antibody and test LSAB2-HRP to visualize IL-6/Ab complexes. smooth muscle cells in response to stimulation by In slices of the pancreas, derived from patients with CP, a much endotoxin, IL-1, tumor necrosis factor-a and has a wide stronger immunohistochemical reaction was noticed as com- variety of biologic, differentiation, and growth-promoting pared with controls specimens. IL-6 was localized in exocrine, 8,9 effects in a variety of target

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jan 1, 2008

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