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Immunohistochemical Expression of Estrogen Receptor in Adenocarcinomas of the Lung The Antibody Factor

Immunohistochemical Expression of Estrogen Receptor in Adenocarcinomas of the Lung The Antibody... RESEARCH ARTICLE Immunohistochemical Expression of Estrogen Receptor in Adenocarcinomas of the Lung The Antibody Factor Carmen Gomez-Fernandez, MD,* Aldo Mejias, MD,* Gail Walker, PhD,w and Mehrdad Nadji, MD* for all of the antibodies, and for SP1, variation by histologic Background: Immunohistochemistry for estrogen receptor may subtype was significant (P<0.001). be used to distinguish metastatic breast cancers from adenocar- Conclusions: SP1 has a significantly higher detection rate for the cinomas of other sites, including those of the lung. The estrogen expression of estrogen receptor in pulmonary adenocarcinomas receptor exists as 2 subtypes, a and b. Estrogen receptor a is when compared with either 1D5 or 6F11. Caution should there- the predominant subtype expressed by more than two-thirds of fore be exercised in the use of this antibody alone in distinguishing human breast cancers. Adenocarcinomas of lung origin may a metastatic breast from a primary pulmonary adenocarcinoma. also express estrogen receptor, primarily the b subtype. Human estrogen receptor a is highly homologous to estrogen receptor b Key Words: estrogen receptor, immunohistochemistry, pulmo- and consequently, antibodies used to detect estrogen receptor a nary adenocarcinomas in breast carcinomas may detect estrogen receptor b in pulmo- (Appl Immunohistochem Mol Morphol 2010;18:137–141) nary adenocarcinomas. We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Immunohistochemical Expression of Estrogen Receptor in Adenocarcinomas of the Lung The Antibody Factor

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181bec23b
pmid
19875957
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Immunohistochemical Expression of Estrogen Receptor in Adenocarcinomas of the Lung The Antibody Factor Carmen Gomez-Fernandez, MD,* Aldo Mejias, MD,* Gail Walker, PhD,w and Mehrdad Nadji, MD* for all of the antibodies, and for SP1, variation by histologic Background: Immunohistochemistry for estrogen receptor may subtype was significant (P<0.001). be used to distinguish metastatic breast cancers from adenocar- Conclusions: SP1 has a significantly higher detection rate for the cinomas of other sites, including those of the lung. The estrogen expression of estrogen receptor in pulmonary adenocarcinomas receptor exists as 2 subtypes, a and b. Estrogen receptor a is when compared with either 1D5 or 6F11. Caution should there- the predominant subtype expressed by more than two-thirds of fore be exercised in the use of this antibody alone in distinguishing human breast cancers. Adenocarcinomas of lung origin may a metastatic breast from a primary pulmonary adenocarcinoma. also express estrogen receptor, primarily the b subtype. Human estrogen receptor a is highly homologous to estrogen receptor b Key Words: estrogen receptor, immunohistochemistry, pulmo- and consequently, antibodies used to detect estrogen receptor a nary adenocarcinomas in breast carcinomas may detect estrogen receptor b in pulmo- (Appl Immunohistochem Mol Morphol 2010;18:137–141) nary adenocarcinomas. We

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2010

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