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Immunohistochemical Evaluation of Leptin Expression in Wound Healing A Clue to Exuberant Scar Formation

Immunohistochemical Evaluation of Leptin Expression in Wound Healing A Clue to Exuberant Scar... RESEARCH ARTICLE Immunohistochemical Evaluation of Leptin Expression in Wound Healing: A Clue to Exuberant Scar Formation Iman Seleit, MD,* Ola A. Bakry, MD,* Rehab M. Samaka, MD,w and Amira S. Tawfik, MSc* he wound healing process is a complex group of bio- Abstract: Leptin has been recognized as an important factor for Tchemical and cellular events designed to achieve promoting normal cutaneous wound healing. The aim of this restoration of tissue integrity. The classic model of wound work was to explore leptin expression in keloid and hypertrophic healing is divided into 4 overlapping phases including scars (HS) compared with surgical scars and normal skin. The 1 hemostasis, inflammation, proliferation, and remodeling. relationship of this expression with clinicopathologic parameters These phases are regulated by several mediators in- of studied cases was also evaluated. Using immunohistochemical cluding platelets, inflammatory cells, vascular endothelial techniques, leptin was analyzed in skin biopsies of 60 nonobese cells, fibroblasts, cytokines, growth factors, matrix metal- subjects without metabolic syndrome who presented with keloids loproteinases, and tissue inhibitors of matrix metal- (20), HS (20), and surgical scars (20). Twenty normal skin sam- 2 loproteinases. ples, from age-matched, sex-matched, and body mass index- Dysregulation in certain stages of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Immunohistochemical Evaluation of Leptin Expression in Wound Healing A Clue to Exuberant Scar Formation

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Aug 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000187
pmid
26258753
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Immunohistochemical Evaluation of Leptin Expression in Wound Healing: A Clue to Exuberant Scar Formation Iman Seleit, MD,* Ola A. Bakry, MD,* Rehab M. Samaka, MD,w and Amira S. Tawfik, MSc* he wound healing process is a complex group of bio- Abstract: Leptin has been recognized as an important factor for Tchemical and cellular events designed to achieve promoting normal cutaneous wound healing. The aim of this restoration of tissue integrity. The classic model of wound work was to explore leptin expression in keloid and hypertrophic healing is divided into 4 overlapping phases including scars (HS) compared with surgical scars and normal skin. The 1 hemostasis, inflammation, proliferation, and remodeling. relationship of this expression with clinicopathologic parameters These phases are regulated by several mediators in- of studied cases was also evaluated. Using immunohistochemical cluding platelets, inflammatory cells, vascular endothelial techniques, leptin was analyzed in skin biopsies of 60 nonobese cells, fibroblasts, cytokines, growth factors, matrix metal- subjects without metabolic syndrome who presented with keloids loproteinases, and tissue inhibitors of matrix metal- (20), HS (20), and surgical scars (20). Twenty normal skin sam- 2 loproteinases. ples, from age-matched, sex-matched, and body mass index- Dysregulation in certain stages of the

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Aug 1, 2015

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