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Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Immunohistochemical Comparative Analysis of Cell Proliferation and Angiogenic Index in Squamous Cell Carcinomas of the Tongue Between Young and Older Patients Thaı´s Gomes Benevenuto, DDS, MSc, Cassiano Francisco Weege Nonaka, DDS, PhD, Lea˜o Pereira Pinto, DDS, PhD, and Le´lia Batista de Souza, DDS, PhD ral squamous cell carcinoma (OSCC) is a malignant Abstract: Oral squamous cell carcinoma (SCC) is a malignant Oepithelial tumor that primarily affects men between 1,2 epithelial tumor that is uncommon in individuals younger than the sixth and seventh decades of life and is commonly 45 years. This study compared the cell proliferation and located in the tongue. This tumor is uncommon in angiogenic index in SCCs of the tongue between young and individuals younger than 45 years, accounting for 4% to 2,4,5 older patients. Forty SCCs of the tongue, 20 diagnosed in young 13% of all cases of OSCC. The results of studies patients (r40 y) and 20 diagnosed in older patients (>50 y) were investigating the biological behavior of OSCCs in young evaluated by immunohistochemistry. Cell proliferation was and older patients are conflicting. Some of these studies evaluated using the Ki-67 labeling index (LI). The
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: May 1, 2012
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