Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Thirty-five cases of invasive breast carcinomas in formalin-fixed, paraffin-embedded tissue sections were examined and scored for estrogen receptor (ER) and progesterone receptor (PR) proteins, tumor vascularity as determined by factor VIII-associated antigen (factor VIII) immunostaining, and proliferative activity as determined by proliferating cell nuclear antigen (PCNA) immunoreactivity. There was a high correlation between the immunohistochemical (IHC) scores and biochemical values for both ER and PR (p< 0.001). The IHC analysis was able to detect more cases that were both ER and PR positive compared to the biochemical assay (58% vs. 48%). Comparison of tumor vascularity and PCNA IHC score revealed that carcinomas with greater neovascularization showed greater proliferative activity (p= 0.008). Carcinomas with higher PCNA scores and tumor vascularity were more likely to have metastasized to lymph nodes, but these associations were not statistically significant. These results indicate that markers with important prognostic significance such as ER and PR can be readily performed in routinely processed tissue sections, and that immunohistochemical analysis of tumor neovascularization and proliferation in routinely processed tissues may be useful in predicting the behavior of breast carcinomas.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jan 1, 1993
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.