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/lp/wolters-kluwer-health/immunohistochemical-analysis-of-breast-carcinoma-estrogen-and-do0NuIeh9x
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- ISSN
- 1062-3345
- eISSN
- 1533-4058
Abstract
This study describes an immunohistochemical technique using two new, commercially available monoclonal antibodies to localize estrogen and progesterone receptors in formalin-fixed, paraffin-embedded tissue. Immunoperoxidase staining with these antibodies was preceded by microwave heat to expose antigenic sites. In 40 breast cancer specimens studied by both an enzyme immunoassay technique and paraffin immunohistochemistry, agreement on receptor status was found for estrogen receptor in 39 cases (98%) and for progesterone receptor in 33 cases (83%). The immunohistochemical technique provides an excellent correlation between histology and receptor status. These results demonstrate that immunohistochemical analysis with anti-estrogen receptor ER1D5 and anti-progesterone receptor 1A6 provides a reliable and reproducible alternative for hormone receptor assessment when tissue is unavailable for cytosol-based analysis.
Journal
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jan 1, 1993