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Immunocytochemical Increased Evidence of Inducible Nitric Oxide Synthase, Tumor Necrosis Factor-&agr;, and Adrenocorticotropic Hormone in Human Peritumoral Lymph Nodes

Immunocytochemical Increased Evidence of Inducible Nitric Oxide Synthase, Tumor Necrosis... In the current study, mesenteric and peritumoral lymph nodes surgically removed from patients with colon-rectum cancer were studied. Morphologic and immunocytochemical investigations demonstrated that mesenteric (control) and peritumoral lymph nodes of a same patient showed the same morphologic structure, but a different immunocytochemical pattern. Indeed, an increased immunoreactivity to anti–inducible nitric oxide synthase, anti–tumor necrosis factor-&agr;, and anti-adrenocorticotropic hormone antibodies in the lymphatic tissue of peritumoral lymph nodes compared with mesenteric lymph nodes was observed. These findings suggest that in colon-rectum cancer, the pathologic event induces an increased expression of the molecules involved in the processes of inflammation and carcinogenesis that occurs earlier than the appearance of morphologic modifications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Immunocytochemical Increased Evidence of Inducible Nitric Oxide Synthase, Tumor Necrosis Factor-&agr;, and Adrenocorticotropic Hormone in Human Peritumoral Lymph Nodes

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ISSN
1062-3345
eISSN
1533-4058

Abstract

In the current study, mesenteric and peritumoral lymph nodes surgically removed from patients with colon-rectum cancer were studied. Morphologic and immunocytochemical investigations demonstrated that mesenteric (control) and peritumoral lymph nodes of a same patient showed the same morphologic structure, but a different immunocytochemical pattern. Indeed, an increased immunoreactivity to anti–inducible nitric oxide synthase, anti–tumor necrosis factor-&agr;, and anti-adrenocorticotropic hormone antibodies in the lymphatic tissue of peritumoral lymph nodes compared with mesenteric lymph nodes was observed. These findings suggest that in colon-rectum cancer, the pathologic event induces an increased expression of the molecules involved in the processes of inflammation and carcinogenesis that occurs earlier than the appearance of morphologic modifications.

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Mar 1, 2002

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