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Immune Mechanisms in Atherosclerosis

Immune Mechanisms in Atherosclerosis Review Goran K. Hansson, Lena Jonasson, Paul S. Seifert, and Sten Stemme he atherosclerotic plaque bears many similarities to Monocytes and Macrophages T chronic inflammatory conditions, perhaps the most One of the major functions of macrophages is to striking one being the accumulation of macrophages in participate in the immune response by presenting foreign both situations. This has been pointed out repeatedly antigen to T lymphocytes. The macrophage internalizes over the years, and Rudolf Virchow described athero- foreign antigens by endocytosis, partially degrades them sclerosis as a chronic irritation of the vessel wall. Poole in its lysosomes, and then transfers antigen fragments, to and Florey, in their classic papers on the effects of the cell surface. The fragments associate with polymor- mechanical injury to the aorta, pointed out the involve- phic cell-surface MHC proteins, and the antigen receptor ment of leukocytes in the response to injury process. A of the T lymphocyte binds to this macromolecular complex 3 1011 few years later, Roberts found that serum sickness sig- on the macrophage surface. nificantly aggravates cholesterol-induced atherosclero- Studies involving cholesterol-fed animals in the latter sis. Minick and Murphy subsequently elucidated the part of the 1970s re-emphasized the importance of mono- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Immune Mechanisms in Atherosclerosis

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Copyright
© 1989 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Review Goran K. Hansson, Lena Jonasson, Paul S. Seifert, and Sten Stemme he atherosclerotic plaque bears many similarities to Monocytes and Macrophages T chronic inflammatory conditions, perhaps the most One of the major functions of macrophages is to striking one being the accumulation of macrophages in participate in the immune response by presenting foreign both situations. This has been pointed out repeatedly antigen to T lymphocytes. The macrophage internalizes over the years, and Rudolf Virchow described athero- foreign antigens by endocytosis, partially degrades them sclerosis as a chronic irritation of the vessel wall. Poole in its lysosomes, and then transfers antigen fragments, to and Florey, in their classic papers on the effects of the cell surface. The fragments associate with polymor- mechanical injury to the aorta, pointed out the involve- phic cell-surface MHC proteins, and the antigen receptor ment of leukocytes in the response to injury process. A of the T lymphocyte binds to this macromolecular complex 3 1011 few years later, Roberts found that serum sickness sig- on the macrophage surface. nificantly aggravates cholesterol-induced atherosclero- Studies involving cholesterol-fed animals in the latter sis. Minick and Murphy subsequently elucidated the part of the 1970s re-emphasized the importance of mono-

Journal

Arteriosclerosis – Wolters Kluwer Health

Published: Sep 1, 1989

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