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Imaging of Gastrointestinal Stromal Tumors

Imaging of Gastrointestinal Stromal Tumors PICTORIAL ESSAY:ABDOMINAL IMAGING Hyo-Cheol Kim,* Jeong Min Lee,* Seung Hong Choi,* Kyoung Won Kim,† Se Hyung Kim,* Jae Young Lee,* Joon Koo Han,* and Byung Ihn Choi* tion in the c-kit proto-oncogene, resulting in activation of the Abstract: Gastrointestinal stromal tumors (GISTs) are the most KIT receptor tyrosine kinase and an unopposed stimulus for common mesenchymal neoplasms of the gastrointestinal tract and are cell growth. STI-571 is a small molecule that selectively in- defined by their expression of KIT (CD117). This article includes 109 hibits KIT tyrosine kinase and marks a new era of targeted pathologically proven GISTs, with emphasis on their various com- molecular inhibition of cancer. puted tomography (CT) features. Although the images of GISTs on Gastrointestinal stromal tumors occur most frequently in the CT scan are often distinct from those of epithelial tumors, radi- the stomach (70%), followed by the small intestine (20%– ologists should be familiar with these features for the accurate diag- 30%), rectum, colon, and esophagus. They may also occur nosis of GISTs. primarily in the omentum, mesentery, and retroperitoneum. Key Words: gastrointestinal stromal tumor; gastrointestinal tract, Although leiomyomas predominate in the esophagus, GISTs neoplasms; gastrointestinal tract, computed tomography account for almost all http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Computer Assisted Tomography Wolters Kluwer Health

Imaging of Gastrointestinal Stromal Tumors

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References (14)

Copyright
Copyright © 2004 by Lippincott Williams & Wilkins
ISSN
0363-8715
eISSN
1532-3145
DOI
10.1097/01.rct.0000138988.23480.db
Publisher site
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Abstract

PICTORIAL ESSAY:ABDOMINAL IMAGING Hyo-Cheol Kim,* Jeong Min Lee,* Seung Hong Choi,* Kyoung Won Kim,† Se Hyung Kim,* Jae Young Lee,* Joon Koo Han,* and Byung Ihn Choi* tion in the c-kit proto-oncogene, resulting in activation of the Abstract: Gastrointestinal stromal tumors (GISTs) are the most KIT receptor tyrosine kinase and an unopposed stimulus for common mesenchymal neoplasms of the gastrointestinal tract and are cell growth. STI-571 is a small molecule that selectively in- defined by their expression of KIT (CD117). This article includes 109 hibits KIT tyrosine kinase and marks a new era of targeted pathologically proven GISTs, with emphasis on their various com- molecular inhibition of cancer. puted tomography (CT) features. Although the images of GISTs on Gastrointestinal stromal tumors occur most frequently in the CT scan are often distinct from those of epithelial tumors, radi- the stomach (70%), followed by the small intestine (20%– ologists should be familiar with these features for the accurate diag- 30%), rectum, colon, and esophagus. They may also occur nosis of GISTs. primarily in the omentum, mesentery, and retroperitoneum. Key Words: gastrointestinal stromal tumor; gastrointestinal tract, Although leiomyomas predominate in the esophagus, GISTs neoplasms; gastrointestinal tract, computed tomography account for almost all

Journal

Journal of Computer Assisted Tomography – Wolters Kluwer Health

Published: Sep 1, 2004

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