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IL-17 and Th17 Cells in Atherosclerosis Subtle and Contextual Roles

IL-17 and Th17 Cells in Atherosclerosis Subtle and Contextual Roles ATVB in Focus Modulation of Atherosclerotic Lesions by Circulating Cells: The Translational Spectrum Series Editors: Theo J. van Berkel and Johan Kuiper IL-17 and Th17 Cells in Atherosclerosis Subtle and Contextual Roles Soraya Taleb, Alain Tedgui, Ziad Mallat Abstract—Atherosclerosis is a chronic inflammatory arterial disease driven by both innate and adaptive immune responses to modified lipoproteins and components of the injured vascular wall. Specific T lymphocyte responses driven by T helper-1 or T regulatory cells play distinct and opposing roles in atherosclerosis. More recently, T helper-17 cells, which produce the prototype cytokine interleukin-17, have been characterized and shown to be critical in mucosal host defense against microbial and fungal pathogens. Sustained production of interleukin-17 in an inflammatory context has been linked to the pathology of several autoimmune and inflammatory diseases. However, regulatory and protective roles have also been reported in selective disease settings. Studies in atherosclerosis led to conflicting results on the roles of interleukin-17 and T helper-17 cells in disease development and plaque stability. The present review provides a summary of the available evidence and putative mechanisms linking this pathway to atherosclerosis, as well as a perspective on the risks and benefits of interleukin-17–targeted cytokine therapy in patients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

IL-17 and Th17 Cells in Atherosclerosis Subtle and Contextual Roles

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References (83)

Copyright
© 2014 American Heart Association, Inc.
ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.114.303567
pmid
25234818
Publisher site
See Article on Publisher Site

Abstract

ATVB in Focus Modulation of Atherosclerotic Lesions by Circulating Cells: The Translational Spectrum Series Editors: Theo J. van Berkel and Johan Kuiper IL-17 and Th17 Cells in Atherosclerosis Subtle and Contextual Roles Soraya Taleb, Alain Tedgui, Ziad Mallat Abstract—Atherosclerosis is a chronic inflammatory arterial disease driven by both innate and adaptive immune responses to modified lipoproteins and components of the injured vascular wall. Specific T lymphocyte responses driven by T helper-1 or T regulatory cells play distinct and opposing roles in atherosclerosis. More recently, T helper-17 cells, which produce the prototype cytokine interleukin-17, have been characterized and shown to be critical in mucosal host defense against microbial and fungal pathogens. Sustained production of interleukin-17 in an inflammatory context has been linked to the pathology of several autoimmune and inflammatory diseases. However, regulatory and protective roles have also been reported in selective disease settings. Studies in atherosclerosis led to conflicting results on the roles of interleukin-17 and T helper-17 cells in disease development and plaque stability. The present review provides a summary of the available evidence and putative mechanisms linking this pathway to atherosclerosis, as well as a perspective on the risks and benefits of interleukin-17–targeted cytokine therapy in patients

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Feb 1, 2015

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