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Downloaded from http://journals.lww.com/co-hivandaids by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/12/2020 HIV-1 infection and induction of interferon alpha in plasmacytoid dendritic cells Adel Benlahrech and Steven Patterson Department of Immunology, Imperial College London, Purpose of review Chelsea and Westminster Hospital, London, UK Loss of blood plasmacytoid dendritic cell (pDC) in HIV-1 infection is thought to impact Correspondence to Steven Patterson, Immunology on adaptive immune responses whilst the virus also induces aberrant interferon alpha Section, Division of Infectious Diseases, Imperial (IFN-a) production that may fuel chronic immune activation and drive disease College, Chelsea & Westminster Hospital, 369 Fulham Road, London, UK progression. Recent attention has focussed on the pathway of HIV-induced IFN-a Tel: +44 203 315 5934; fax: +44 203 315 5997; production by pDC and the new data are reviewed here together with the pathway e-mail: s.patterson@imperial.ac.uk leading to infection. Current Opinion in HIV and AIDS 2011, Recent findings 6:373–378 Attachment to CD4 and chemokine co-receptors is essential for HIV-1 infection. Although CD4, but not co-receptor binding, is a major route for passage to endosomes and triggering of IFN-a secretion this may also occur by CD4-independent mechanisms involving other receptors. In contrast to other Toll-like receptor (TLR)-7 ligands and RNA viruses that stimulate
Current Opinion in HIV & AIDS – Wolters Kluwer Health
Published: Sep 1, 2011
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