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Histone deacetylase inhibitors and HIV latency

Histone deacetylase inhibitors and HIV latency David M. Margolis Institute for Global Health and Infectious Diseases, Purpose of review University of North Carolina at Chapel Hill, Chapel Hill, Interest has re-emerged in approaches to eradicate HIV infection. A series of North Carolina, USA modifications of nucleosomal histones within chromatin are a key mechanism of HIV Correspondence to David M. Margolis, MD, FACP, gene regulation that alters the recruitment of transcription factors to viral DNA. The University of North Carolina at Chapel Hill, 2060 Genetic Medicine Bldg, CB#7042 Chapel Hill, NC balance of these histone modifications in the vicinity of the HIV LTR plays an important 27599-7042, USA role in the maintenance of proviral quiescence in rare latently infected cells, and Tel: +1 919 966 6388; fax: +1 919 843 9976; e-mail: dmargo@med.unc.edu presents a target for therapies aimed at purging this reservoir of persistent HIV infection. Recent findings Current Opinion in HIV and AIDS 2011, 6:25–29 Altering the balance of acetylase and deacetylase activity within CD4 lymphocytes using histone deacetylase (HDAC) inhibitors, or other epigenetic drugs, has recently emerged as a promising approach to purge the reservoir of persistent infection. Multiple molecular mechanisms appear to underlie the establishment and maintenance of persistent, latent HIV infection, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Histone deacetylase inhibitors and HIV latency

Margolis, David M
Current Opinion in HIV and Aids , Volume 6 (1) – Jan 1, 2011
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References (44)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328341242d
pmid
21242890
Publisher site
See Article on Publisher Site

Abstract

David M. Margolis Institute for Global Health and Infectious Diseases, Purpose of review University of North Carolina at Chapel Hill, Chapel Hill, Interest has re-emerged in approaches to eradicate HIV infection. A series of North Carolina, USA modifications of nucleosomal histones within chromatin are a key mechanism of HIV Correspondence to David M. Margolis, MD, FACP, gene regulation that alters the recruitment of transcription factors to viral DNA. The University of North Carolina at Chapel Hill, 2060 Genetic Medicine Bldg, CB#7042 Chapel Hill, NC balance of these histone modifications in the vicinity of the HIV LTR plays an important 27599-7042, USA role in the maintenance of proviral quiescence in rare latently infected cells, and Tel: +1 919 966 6388; fax: +1 919 843 9976; e-mail: dmargo@med.unc.edu presents a target for therapies aimed at purging this reservoir of persistent HIV infection. Recent findings Current Opinion in HIV and AIDS 2011, 6:25–29 Altering the balance of acetylase and deacetylase activity within CD4 lymphocytes using histone deacetylase (HDAC) inhibitors, or other epigenetic drugs, has recently emerged as a promising approach to purge the reservoir of persistent infection. Multiple molecular mechanisms appear to underlie the establishment and maintenance of persistent, latent HIV infection,

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Jan 1, 2011

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