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Histologic, Immunohistochemical, and Molecular Classification of 52 IPMNs of the Pancreas

Histologic, Immunohistochemical, and Molecular Classification of 52 IPMNs of the Pancreas RESEARCH ARTICLE Histologic, Immunohistochemical, and Molecular Classification of 52 IPMNs of the Pancreas Barbara Chadwick, MD,* Carlynn Willmore-Payne, BS, MT (ASCP),w Sheryl Tripp, BS, MT (ASCP), QIHC (ASCP),w Lester J. Layfield, MD,* Sharon Hirschowitz, MD,z and Joseph Holden, MD, PhD* ntraductal papillary mucinous neoplasms (IPMNs) are Background: Intraductal papillary mucinous neoplasms Ia well recognized clinical entity with a characteristic (IPMNs) of the pancreas account for approximately 5% of ultrasonographic and gross appearance in which the main pancreatic neoplasms. Prognosis is superior to that of pancreatic pancreatic duct or branch ducts are ectatic and contain invasive ductal carcinoma. IPMNs reveal a variety of epithelial a mucin-producing epithelial proliferation often with a 1–5 linings expressing different mucin staining patterns and may papillary architecture. These neoplasms can be sepa- progress along different oncogenic pathways. rated from mucinous cystic tumors by the former’s characteristic communication with and dilatation of the Materials and Methods: Fifty-two IPMNs were studied for main pancreatic duct or branch ducts. Additionally, expression of MUC1, MUC2, p16, p21, HER2, cyclin D1, and mucinous cystic tumors characteristically contained p53 protein and for mutations in K-ras, HER2, p53, EGFR, and an ovarianlike stroma and are predominantly seen BRAF genes. The cases were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Histologic, Immunohistochemical, and Molecular Classification of 52 IPMNs of the Pancreas

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31817c02c6
pmid
18813127
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Histologic, Immunohistochemical, and Molecular Classification of 52 IPMNs of the Pancreas Barbara Chadwick, MD,* Carlynn Willmore-Payne, BS, MT (ASCP),w Sheryl Tripp, BS, MT (ASCP), QIHC (ASCP),w Lester J. Layfield, MD,* Sharon Hirschowitz, MD,z and Joseph Holden, MD, PhD* ntraductal papillary mucinous neoplasms (IPMNs) are Background: Intraductal papillary mucinous neoplasms Ia well recognized clinical entity with a characteristic (IPMNs) of the pancreas account for approximately 5% of ultrasonographic and gross appearance in which the main pancreatic neoplasms. Prognosis is superior to that of pancreatic pancreatic duct or branch ducts are ectatic and contain invasive ductal carcinoma. IPMNs reveal a variety of epithelial a mucin-producing epithelial proliferation often with a 1–5 linings expressing different mucin staining patterns and may papillary architecture. These neoplasms can be sepa- progress along different oncogenic pathways. rated from mucinous cystic tumors by the former’s characteristic communication with and dilatation of the Materials and Methods: Fifty-two IPMNs were studied for main pancreatic duct or branch ducts. Additionally, expression of MUC1, MUC2, p16, p21, HER2, cyclin D1, and mucinous cystic tumors characteristically contained p53 protein and for mutations in K-ras, HER2, p53, EGFR, and an ovarianlike stroma and are predominantly seen BRAF genes. The cases were

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2009

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