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Higher TGF-&bgr; With Lower CD124 and TSLP, But No Difference in PAR-2 Expression in Bronchial Biopsy of Bronchial Asthma Patients in Comparison With COPD Patients

Higher TGF-&bgr; With Lower CD124 and TSLP, But No Difference in PAR-2 Expression in Bronchial... RESEARCH ARTICLE Higher TGF-b With Lower CD124 and TSLP, But No Difference in PAR-2 Expression in Bronchial Biopsy of Bronchial Asthma Patients in Comparison With COPD Patients Radoslav Mateˇj, MD, PhD,*w Martina Vasˇa´kova´, MD, PhD,z Jaromı´r Kukal, PhD,y Martina Sterclova´, MD, PhD,z and Toma´sˇ Oleja´r, MD, PhD*8 n chronic obstructive pulmonary disease (COPD), the Abstract: Chronic obstructive pulmonary disease (COPD) and ITh1 immune reaction predominates, whereas in bron- bronchial asthma (BA) are 2 severe respiratory disorders with chial asthma (BA) Th2 immunity is primarily involved. different predominated immunopathologies. There are several There are several “novel molecules” from different fami- “novel molecules” from different families that are proposed as lies that are proposed as part of the etiopathogenesis and part of the etiopathogenesis of COPD and BA. Proteinase- development of COPD and BA. These molecules modu- activated receptor 2 (PAR-2), thymic stromal lymphoprotein late different inflammatory properties and subsequently (TSLP), interleukin-4 and its receptor (CD124), Yin-Yang 1 the clinical and morphologic appearance of both diseases. (YY1), and transforming growth factor beta (TGF-b) have been Proteinase-activated receptor 2 (PAR-2) is activated by, previously shown to be involved in the pathophysiology of both among others, trypsin, mast cell tryptase, Alternaria al- these http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Higher TGF-&bgr; With Lower CD124 and TSLP, But No Difference in PAR-2 Expression in Bronchial Biopsy of Bronchial Asthma Patients in Comparison With COPD Patients

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3182a500a3
pmid
24185116
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Higher TGF-b With Lower CD124 and TSLP, But No Difference in PAR-2 Expression in Bronchial Biopsy of Bronchial Asthma Patients in Comparison With COPD Patients Radoslav Mateˇj, MD, PhD,*w Martina Vasˇa´kova´, MD, PhD,z Jaromı´r Kukal, PhD,y Martina Sterclova´, MD, PhD,z and Toma´sˇ Oleja´r, MD, PhD*8 n chronic obstructive pulmonary disease (COPD), the Abstract: Chronic obstructive pulmonary disease (COPD) and ITh1 immune reaction predominates, whereas in bron- bronchial asthma (BA) are 2 severe respiratory disorders with chial asthma (BA) Th2 immunity is primarily involved. different predominated immunopathologies. There are several There are several “novel molecules” from different fami- “novel molecules” from different families that are proposed as lies that are proposed as part of the etiopathogenesis and part of the etiopathogenesis of COPD and BA. Proteinase- development of COPD and BA. These molecules modu- activated receptor 2 (PAR-2), thymic stromal lymphoprotein late different inflammatory properties and subsequently (TSLP), interleukin-4 and its receptor (CD124), Yin-Yang 1 the clinical and morphologic appearance of both diseases. (YY1), and transforming growth factor beta (TGF-b) have been Proteinase-activated receptor 2 (PAR-2) is activated by, previously shown to be involved in the pathophysiology of both among others, trypsin, mast cell tryptase, Alternaria al- these

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Aug 1, 2014

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