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HGAL Protein Expression Persists in Disorders of Germinal Center Dissolution: Potential Role of HGAL in the Germinal Center Microenvironment

HGAL Protein Expression Persists in Disorders of Germinal Center Dissolution: Potential Role of... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE HGAL Protein Expression Persists in Disorders of Germinal Center Dissolution Potential Role of HGAL in the Germinal Center Microenvironment Caroline Temmins, MD,* Shuchun Zhao, MS,* Izidore S. Lossos, MD,w and Yasodha Natkunam, MD, PhD* human homolog of the mouse gene M17,which is Abstract: Human Germinal Center-associated Lymphoma expressedinnormalGCB-cells. Studies in mice showed (HGAL) is a germinal center (GC) B-cell marker associated that HGAL is dispensable for GC formation, immunoglo- with a favorable outcome in diffuse large B-cell and classic bulin class switch recombination and somatic hypermuta- Hodgkin lymphomas (CHL). To test its potential role in GC tion; however, M17 knockout mice exhibit smaller GCs function, 75 cases involving GC disruption including compared with their wild-type littermates. We earlier 23 progressive transformation of germinal centers (PTGC), showed that the HGAL protein is expressed in human GC 25 follicle lysis and 27 Castleman disease (CD) were studied. B-cells and in lymphomas of GC B-cell derivation. Of HGAL protein expression uniformly correlated with GC B-cells note, HGAL protein is expressed in Hodgkin/Reed in all except a subset of hyaline-vascular CD that showed severe Sternberg cells of CHL, although these cells show loss of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

HGAL Protein Expression Persists in Disorders of Germinal Center Dissolution: Potential Role of HGAL in the Germinal Center Microenvironment

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References (32)

Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181f89a4d
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE HGAL Protein Expression Persists in Disorders of Germinal Center Dissolution Potential Role of HGAL in the Germinal Center Microenvironment Caroline Temmins, MD,* Shuchun Zhao, MS,* Izidore S. Lossos, MD,w and Yasodha Natkunam, MD, PhD* human homolog of the mouse gene M17,which is Abstract: Human Germinal Center-associated Lymphoma expressedinnormalGCB-cells. Studies in mice showed (HGAL) is a germinal center (GC) B-cell marker associated that HGAL is dispensable for GC formation, immunoglo- with a favorable outcome in diffuse large B-cell and classic bulin class switch recombination and somatic hypermuta- Hodgkin lymphomas (CHL). To test its potential role in GC tion; however, M17 knockout mice exhibit smaller GCs function, 75 cases involving GC disruption including compared with their wild-type littermates. We earlier 23 progressive transformation of germinal centers (PTGC), showed that the HGAL protein is expressed in human GC 25 follicle lysis and 27 Castleman disease (CD) were studied. B-cells and in lymphomas of GC B-cell derivation. Of HGAL protein expression uniformly correlated with GC B-cells note, HGAL protein is expressed in Hodgkin/Reed in all except a subset of hyaline-vascular CD that showed severe Sternberg cells of CHL, although these cells show loss of

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: May 1, 2011

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