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Hemostasis and Vascular Dementia

Hemostasis and Vascular Dementia Editorial Philip M.W. Bath, Peter R. Anderton, Sandeep Ankolekar ascular dementia (VaD) comprises a group of syn- von Willebrand factor) were not associated with cognitive Vdromes caused by vascular lesions in the brain. Cogni- decline. tive impairment may follow a single cortical or lacunar Second, Gallacher and colleagues present data on 865 infarct in a strategic area of the brain, multiple infarcts, men free of vascular disease, with biomarker measurements, small-vessel disease (leukoaraiosis), intracerebral hemor- who were observed in the Caerphilly community cohort. rhage, or any of these conditions coexisting with Alzheimer Hemostasis factors were measured at the age of 45 to 59 dementia (so-called mixed dementia). Depending on case mix years, and cognition and dementia were determined up to the and the type of observational study, 10% of patients already age of 65 to 84 years. During 17 years of follow-up, 59 of the have dementia before their first stroke, 10% develop it soon men developed dementia and 112 developed cognitive im- after their first stroke, and more than 33% have dementia after pairment/no dementia. Increased fibrinogen, factor VIII, and a recurrent stroke. Typically, dementia develops at a rate of plasminogen activator inhibitor-1 levels were associated in- 3% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

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ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.109.200824
pmid
20167665
Publisher site
See Article on Publisher Site

Abstract

Editorial Philip M.W. Bath, Peter R. Anderton, Sandeep Ankolekar ascular dementia (VaD) comprises a group of syn- von Willebrand factor) were not associated with cognitive Vdromes caused by vascular lesions in the brain. Cogni- decline. tive impairment may follow a single cortical or lacunar Second, Gallacher and colleagues present data on 865 infarct in a strategic area of the brain, multiple infarcts, men free of vascular disease, with biomarker measurements, small-vessel disease (leukoaraiosis), intracerebral hemor- who were observed in the Caerphilly community cohort. rhage, or any of these conditions coexisting with Alzheimer Hemostasis factors were measured at the age of 45 to 59 dementia (so-called mixed dementia). Depending on case mix years, and cognition and dementia were determined up to the and the type of observational study, 10% of patients already age of 65 to 84 years. During 17 years of follow-up, 59 of the have dementia before their first stroke, 10% develop it soon men developed dementia and 112 developed cognitive im- after their first stroke, and more than 33% have dementia after pairment/no dementia. Increased fibrinogen, factor VIII, and a recurrent stroke. Typically, dementia develops at a rate of plasminogen activator inhibitor-1 levels were associated in- 3%

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Mar 1, 2010

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