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PATHWAY OF THE MONTH Vamsidhar Velcheti, MD,* and Ramaswamy Govindan, MD*† variant and is widely expressed during embryogenesis. Shh Signaling pathways responsible for embryogenesis play a critical acts as a morphogen and plays an important role in the role in the maintenance of stem cells in adult life and cellular formation of the neural tube, axial skeleton, primitive gut, responses to injury. Dysfunction of the developmental signaling 7,8 and the tracheobronchial tree. pathways during adult homeostasis leads to various events resulting Autocatalytic cleavage and coupling of cholesterol are in the development of neoplasia. We review the biology of the the essential posttranslational processes that maintain the hedgehog signaling pathway and its potential role in the develop- signaling capability of the Hh ligands. The secretion of the ment of lung cancer. functional Hh ligand by the Hh-secreting cell is dependent on Key Words: Hedgehog signaling, Lung cancer. the availability of dispatched (Disp), a transmembrane pro- tein with homology to patched (Ptch), which is an Hh recep- (J Thorac Oncol. 2007;2: 7–10) 10,11 tor on the Hh responsive cell. The Ptch 1 and 2 are membrane receptors for Hh ligands. Ptch 1 is more widely expressed and well charac- ignaling pathways
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jan 1, 2007
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