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a,b, a,b, a,b Jorge Esparza-Gordillo , Ingo Marenholz and Young-Ae Lee Pediatric Pneumology and Immunology, Charite´ Purpose of review Universita¨tsmedizin Berlin, Berlin and Max-Delbru¨ ck- The present review summarizes the new discoveries in the genetics of eczema, focusing Centrum (MDC) for Molecular Medicine, Berlin-Buch, Germany on the results from the recently published first genome-wide association study. Recent findings Correspondence to Professor Dr Young-Ae Lee, Pediatric Pneumology and Immunology, Charite The first genome-wide association study for eczema included 10 000 individuals and Campus Virchow Klinikum, Augustenburger Platz 1, provided strong evidence for a new susceptibility locus for eczema in chromosome D-13353 Berlin, Germany Tel: +49 30 9406 35 12; fax: +49 30 9406 31 47; 11q13.5 (P ¼ 7.6 10 ). Importantly, this finding has been confirmed by an e-mail: yo.lee@charite.de independent research group. Homozygous carriers of the risk allele rs7927894[A] Dr Jorge Esparza-Gordillo and Dr Ingo Marenholz represent 11% of the population and their risk of developing eczema is 1.47 times contributed equally to the writing of this article. higher than in no-carriers. This polymorphism also confers risk to Crohn’s disease, Current Opinion in Allergy and Clinical suggesting the locus may be related to epithelial immunity or differentiation.
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Oct 1, 2010
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