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Genetics and the occupational environment

Genetics and the occupational environment Cristina E. Mapp Abbreviations Purpose of review This article will focus on the role of risk factors including AHR airway hyperresponsiveness GST glutathione-S transferase genetic factors in the development of sensitization and HDI hexamethylene diisocyanate occupational asthma. HLA human leukocyte antigen LMWA low-molecular-weight agent Recent findings TDI toluene diisocyanate We will review the recent literature published on the TNF tumour necrosis factor genetics of occupational asthma, especially on genes coding for class II human leukocyte antigen and on respiratory antioxidant mechanisms. We will also discuss 2005 Lippincott Williams & Wilkins 1528-4050 published work on non-occupational asthma and on allergic rhinitis because this information may contribute to a better understanding of the mechanisms involved in occupational asthma and serve to confirm data obtained on the disease. Introduction To date, although some progress has been made in the field Bronchial asthma is common, affecting children and of occupational asthma genetics, most studies were based adults of all ages. Occupational factors account for on small sample sizes, findings were not replicated, and 9 – 15% of the cases of asthma in adults of working age. gene–environment interactions have not yet been Workplace agents induce asthma through two mechan- established. isms: an allergic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Genetics and the occupational environment

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References (50)

ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/01.all.0000162301.74610.21
Publisher site
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Abstract

Cristina E. Mapp Abbreviations Purpose of review This article will focus on the role of risk factors including AHR airway hyperresponsiveness GST glutathione-S transferase genetic factors in the development of sensitization and HDI hexamethylene diisocyanate occupational asthma. HLA human leukocyte antigen LMWA low-molecular-weight agent Recent findings TDI toluene diisocyanate We will review the recent literature published on the TNF tumour necrosis factor genetics of occupational asthma, especially on genes coding for class II human leukocyte antigen and on respiratory antioxidant mechanisms. We will also discuss 2005 Lippincott Williams & Wilkins 1528-4050 published work on non-occupational asthma and on allergic rhinitis because this information may contribute to a better understanding of the mechanisms involved in occupational asthma and serve to confirm data obtained on the disease. Introduction To date, although some progress has been made in the field Bronchial asthma is common, affecting children and of occupational asthma genetics, most studies were based adults of all ages. Occupational factors account for on small sample sizes, findings were not replicated, and 9 – 15% of the cases of asthma in adults of working age. gene–environment interactions have not yet been Workplace agents induce asthma through two mechan- established. isms: an allergic

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Apr 1, 2005

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