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Genetic Susceptibility, Residential Radon, and Lung Cancer in a Radon Prone Area

Genetic Susceptibility, Residential Radon, and Lung Cancer in a Radon Prone Area Original Atricle Genetic Susceptibility, Residential Radon, and  Lung Cancer in a Radon Prone Area Alberto Ruano-Ravina, PharmD, MPH, PhD,*† Marco F. Pereyra, MD,‡ Marta Tojo Castro, MSc, PhD,§║ Mónica Pérez-Ríos, PharmD, MPH, PhD,*† José Abal-Arca, MD,¶ and Juan Miguel Barros-Dios, MD, MPH, PhD*†# Key Words: Lung neoplasms, Residential radon, Genetic Introduction: Radon exposure has been classified as the second susceptibility cause of lung cancer, after tobacco, and the first in never smokers. GSTM1 and GSTT1 genes deletion increase the risk of lung cancer. (J Thorac Oncol. 2014;9: 1073–1080) We aim to know whether the risk of lung cancer because of residen- tial radon is modulated by these genetic polymorphisms. Methods: Hospital-based, case-control study where cases had ung cancer is a major health problem in developed coun- confirmed lung cancer. Cases and controls did not have previous Ltries. It is the leading cause of cancer death in males and neoplasm and were older than 30. Controls attended hospital for females in the United States, according to recent data. Lung noncomplex surgery. We analyzed the results for the whole sample cancer mortality in females doubles that caused by breast can- and separately for never/light smokers and moderate/heavy smokers. 1 cer. Survival has hardly improved in the last 30 years, with a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Genetic Susceptibility, Residential Radon, and Lung Cancer in a Radon Prone Area

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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
eISSN
1556-1380
DOI
10.1097/JTO.0000000000000205
pmid
24852519
Publisher site
See Article on Publisher Site

Abstract

Original Atricle Genetic Susceptibility, Residential Radon, and  Lung Cancer in a Radon Prone Area Alberto Ruano-Ravina, PharmD, MPH, PhD,*† Marco F. Pereyra, MD,‡ Marta Tojo Castro, MSc, PhD,§║ Mónica Pérez-Ríos, PharmD, MPH, PhD,*† José Abal-Arca, MD,¶ and Juan Miguel Barros-Dios, MD, MPH, PhD*†# Key Words: Lung neoplasms, Residential radon, Genetic Introduction: Radon exposure has been classified as the second susceptibility cause of lung cancer, after tobacco, and the first in never smokers. GSTM1 and GSTT1 genes deletion increase the risk of lung cancer. (J Thorac Oncol. 2014;9: 1073–1080) We aim to know whether the risk of lung cancer because of residen- tial radon is modulated by these genetic polymorphisms. Methods: Hospital-based, case-control study where cases had ung cancer is a major health problem in developed coun- confirmed lung cancer. Cases and controls did not have previous Ltries. It is the leading cause of cancer death in males and neoplasm and were older than 30. Controls attended hospital for females in the United States, according to recent data. Lung noncomplex surgery. We analyzed the results for the whole sample cancer mortality in females doubles that caused by breast can- and separately for never/light smokers and moderate/heavy smokers. 1 cer. Survival has hardly improved in the last 30 years, with a

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Aug 1, 2014

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