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Genetic and environmental risk factors for the development of food allergy Bengt Bjo¨rkste´n Purpose of review Introduction To review recent clinical and experimental studies of The aim of previous research into the causes of allergic genetic and environmental risk factors for the development diseases, including food allergy, was mostly to identify of food allergy. potential risk factors in the environment and to identify Recent findings the ‘allergy gene’. No major environmental risk factors It may be true, although it is yet to be shown, that food have been identified, however, and nor are there any allergies in early childhood are becoming more common reliable methods available which identify those indivi- and that the causes are the same as for later-developing duals who will develop allergic disease. Over the past respiratory allergies. The mother not only transfers 50% of 10 years, focus has therefore more been directed against her genes to her baby, but she is also the exclusive protective factors which could enhance the development environment during gestation and continues to be a major of tolerance to allergens. Hypothetically, such factors environmental factor while breast-feeding her infant. Non- were previously encountered early in life, but are now genetic maternal
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Jun 1, 2005
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