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ORIGINAL ARTICLE Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer Patrick Micke, MD, PhD,* Karolina Edlund, BSc,* Lars Holmberg, MD, PhD,†‡§ Hanna Go ¨ ransson Kultima, BSc, Larry Mansouri, PhD,* Simon Ekman, MD, PhD,¶ Michael Bergqvist, MD, PhD,¶ Lena Scheibenflug, MD,* Kristina Lamberg, MD,# Gunnar Myrdal, MD, PhD,** Anders Berglund, BSc,††† Annsofie Andersson, MSc, Mats Lambe, MD, PhD,††† Fredrik Nyberg, MD, PhD,‡‡§§ Andrew Thomas, PhD,¶¶ Anders Isaksson, PhD, and Johan Botling, MD, PhD* ated with shorter survival, whereas losses in a neighboring region, Introduction: Non-small cell lung cancer (NSCLC) is characterized 14q31.1-32.33 (110 genes), correlated with favorable outcome. In by a multitude of genetic aberrations with unknown clinical impact. accordance with copy number gains and losses, messenger RNA In this study, we aimed to identify gene copy number changes that expression levels of corresponding genes were increased or de- correlate with clinical outcome in NSCLC. To maximize the chance creased, respectively. to identify clinically relevant events, we applied a strategy involving Conclusion: Comprehensive tumor profiling permits the integration two prognostically extreme patient groups. of genomic, histologic, and clinical data. We identified gene copy Methods: Short-term (20 month; n 53) and
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Nov 1, 2011
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