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RESEARCH ARTICLE Gastrointestinal Stromal Tumors: Clinical Significance of p53 Expression, MDM2 Amplification, and KIT Mutation Status Michelle L. Wallander, PhD,* Lester J. Layfield, MD,wz Sheryl R. Tripp, BS, MT (ASCP), QIHC(ASCP),* and Robert L. Schmidt, MD, PhD, MBAwz making it the most significant lineage marker for differ- Background: Gastrointestinal stromal tumor (GIST) is the most entiating GISTs from other mesenchymal gastrointestinal common mesenchymal tumor of the gastrointestinal tract. Clinical 2–4 tumors. The majority of GISTs harbor activating behavior is best predicted by size and mitotic count (risk index). mutations in KIT or the closely related tyrosine kinase KIT and platelet-derived growth factor receptor a (PDGFRA) 2,5,6 platelet-derived growth factor receptor a (PDGFRA). mutations have therapeutic and prognostic value but few other Identification of KIT and PDGFRA mutations by muta- prognostically significant molecular markers have been identified. tional analysis is usually not necessary for GIST diagnosis We investigated the prognostic value of p53 protein expression and but is useful for predicting responsiveness to kinase in- MDM2 gene amplification in a series of GISTs. hibitor therapy. Although KIT and PDGFRA play a significant role in GIST oncogenesis, alterations in cell Methods: Thirty-five GISTs were tested for KIT and PDGFRA cycle and
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jul 1, 2013
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