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Editorial Gamma-Glutamyl Transferase Another Biomarker for Metabolic Syndrome and Cardiovascular Risk Scott M. Grundy amma-glutamyl transferase (GGT) is a cell-surface that the liver, which is the primary source of circulating GGT, protein contributing to the extracellular catabolism is a key target organ for the development of the metabolic Gof glutathione (GSH). The enzyme is produced in syndrome. An elevation of GGT is seemingly closely related 10–13 many tissues, but most GGT in serum is derived from the to hepatic steatosis ; the latter in turn is strongly associ- 14–18 liver. In the serum, GGT is carried primarily with lipopro- ated with the metabolic syndrome. The mechanisms teins and albumin. Serum levels of GGT are determined by whereby elevated GGT is related to hepatic steatosis have not several factors: alcohol intake, body fat content, plasma been determined, but several possibilities have been proposed lipid/lipoproteins and glucose levels, and various medica- by Ortega et al. For example, fatty liver could cause 1,3,4 tions. hepatocellular damage that would simulate the synthesis of GGT. Alternatively, excess fat in the liver could enhance See page 127 oxidative stress, leading to overconsumption of GSH with a High levels of GGT have been associated in populations
Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health
Published: Jan 1, 2007
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